2023
Utility of an Artificial Intelligence Language Model for Post-Operative Patient Instructions Following Facial Trauma
Mohan S, Souza S, Fakurnejad S, Knott P. Utility of an Artificial Intelligence Language Model for Post-Operative Patient Instructions Following Facial Trauma. Craniomaxillofacial Trauma & Reconstruction 2023 DOI: 10.1177/19433875231222803.Peer-Reviewed Original ResearchElectronic medical recordsPost-operative instructionsElectronic medical record templatesGoogle search enginePatient Education Materials Assessment ToolFacial traumaTrauma proceduresPEMAT-PProcedure-specific scoresUnderstanding scoresAssessment toolPatient instructionsMedical recordsSearch enginesAction scoresScoresTailored instruction
2022
Super-resolved fluorescence imaging of peripheral nerve
Hernández I, Mohan S, Minderler S, Jowett N. Super-resolved fluorescence imaging of peripheral nerve. Scientific Reports 2022, 12: 12450. PMID: 35864187, PMCID: PMC9304405, DOI: 10.1038/s41598-022-16769-0.Peer-Reviewed Original ResearchConceptsSuper-resolution microscopySuper-resolution imagingNanoscale resolutionSuper-resolution imaging techniquesEmission depletion (STED) microscopyNanoscale cellular structuresStructured illumination microscopyElectron microscopyVisible lightDiffraction limited resolutionDepletion microscopyMicroscopyFluorescence imagingNon-toxic meansIllumination microscopyBiomedical sciencesFluorescent dyeBrightfield microscopyFluorescent objectsSample preparationFluctuation microscopyAutomated stain-free histomorphometry of peripheral nerve by contrast-enhancing techniques and artificial intelligence
Coto Hernández I, Mohan S, Jowett N. Automated stain-free histomorphometry of peripheral nerve by contrast-enhancing techniques and artificial intelligence. Journal Of Neuroscience Methods 2022, 375: 109598. PMID: 35436515, DOI: 10.1016/j.jneumeth.2022.109598.Peer-Reviewed Original ResearchConceptsDeep learning algorithmsDeep learningArtificial intelligenceMachine learningLearning algorithmImage processingImage reconstructionExisting methodsSegmentationPhase contrast imagesLearningContrast imagesImagesIntelligenceAlgorithmEmbeddingBrightfield microscopyTechniqueTransmission modalityProcessingApplications
2020
Considerations in Management of Acute Otitis Media in the COVID-19 Era
Mohan S, Workman A, Barshak M, Welling D, Abdul-Aziz D. Considerations in Management of Acute Otitis Media in the COVID-19 Era. Annals Of Otology Rhinology & Laryngology 2020, 130: 520-527. PMID: 32911957, DOI: 10.1177/0003489420958443.Peer-Reviewed Original ResearchConceptsMiddle ear fluidAcute otitis mediaComplicated acute otitis mediaEar fluidOtitis mediaSARS-CoV-2 infectionSARS-CoV-2Management of Acute Otitis MediaFacial paralysisPCR of nasopharyngeal swabClinical management of patientsPositive viral PCRTreated with myringotomyManagement of patientsBlue light filterCadaveric temporal bonesOtologic findingsSystemic antibioticsEar diseaseNegative PCRAcute infectionClinical managementOtologic proceduresProlonged close contactNasopharyngeal swabsLabel‐free histomorphometry of peripheral nerve by stimulated Raman spectroscopy
Hernández I, Yang W, Mohan S, Jowett N. Label‐free histomorphometry of peripheral nerve by stimulated Raman spectroscopy. Muscle & Nerve 2020, 62: 137-142. PMID: 32304246, DOI: 10.1002/mus.26895.Peer-Reviewed Original ResearchMotor and sensory rehabilitation of the lower lip
Mohan S, Jowett N. Motor and sensory rehabilitation of the lower lip. Operative Techniques In Otolaryngology-Head And Neck Surgery 2020, 31: 45-54. DOI: 10.1016/j.otot.2019.12.010.Peer-Reviewed Original ResearchToward an Automatic System for Computer-Aided Assessment in Facial Palsy
Guarin D, Yunusova Y, Taati B, Dusseldorp J, Mohan S, Tavares J, van Veen M, Fortier E, Hadlock T, Jowett N. Toward an Automatic System for Computer-Aided Assessment in Facial Palsy. Facial Plastic Surgery & Aesthetic Medicine 2020, 22: 42-49. PMID: 32053425, PMCID: PMC7362997, DOI: 10.1089/fpsam.2019.29000.gua.Peer-Reviewed Original ResearchConceptsFacial landmark localizationLandmark localizationMachine learningML algorithmsFacial landmarksAutomatic systemComputer-aided diagnosis systemLocalization accuracyGraphical user interfaceCustom graphical user interfaceLandmark localization accuracyComputer-Aided AssessmentPoor localization accuracyUser interfaceDetection modelMore imagesDiagnosis systemML modelsAvailable algorithmsManual markingNovel ML algorithmsNovel ML modelsLarge databaseAlgorithm accuracyLocalization model
2019
Implantable wireless device for study of entrapment neuropathy
Malka R, Guarin D, Mohan S, Hernández I, Gorelik P, Mazor O, Hadlock T, Jowett N. Implantable wireless device for study of entrapment neuropathy. Journal Of Neuroscience Methods 2019, 329: 108461. PMID: 31626845, PMCID: PMC7325518, DOI: 10.1016/j.jneumeth.2019.108461.Peer-Reviewed Original ResearchConceptsAnimal modelsFunctional lossNeural dysfunctionGrade V injuriesFacial nerve functionSmall animal modelsPartial functional lossComplete functional lossWhisker displacementSurgical decompressionEntrapment syndromeDecompression surgeryNerve functionBell's palsyNerve damageFunctional recoveryGrade IIIFacial nervePeripheral nervesCompartment pressuresMurine modelDisease processInsufficient evidenceLive animal modelsOptimal timingStain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy
Mohan S, Hernández I, Selig M, Shibata S, Jowett N. Stain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy. Journal Of Neuropathology & Experimental Neurology 2019, 78: 1178-1180. PMID: 31642916, PMCID: PMC7967843, DOI: 10.1093/jnen/nlz099.Peer-Reviewed Original ResearchAn Anatomic Variant of the Ansa Cervicalis Precluding Its Use as a Donor Nerve
Zhu A, Mohan S, Richmon J, Jowett N. An Anatomic Variant of the Ansa Cervicalis Precluding Its Use as a Donor Nerve. Annals Of Otology Rhinology & Laryngology 2019, 129: 78-81. PMID: 31510759, DOI: 10.1177/0003489419875975.Peer-Reviewed Original ResearchConceptsAnsa cervicalisAnatomic variantsVagus nerveParotid adenoid cystic carcinomaLeft vocal fold palsyCranial nerve repairFacial nerve resectionIpsilateral hypoglossal nerveRelevant anatomic variantsVocal fold palsyAdenoid cystic carcinomaInterposition repairDonor nerveNerve resectionSural nerveHypoglossal nerveInadvertent injuryNerve epineuriumCystic carcinomaGraft harvestNerve repairApparent morbidityNerveMuscle contractionCervicalis
2018
Outcome Tracking in Facial Palsy
Dusseldorp J, van Veen M, Mohan S, Hadlock T. Outcome Tracking in Facial Palsy. Otolaryngologic Clinics Of North America 2018, 51: 1033-1050. PMID: 30172554, DOI: 10.1016/j.otc.2018.07.003.Peer-Reviewed Original ResearchFluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model
Mohan S, Hernández I, Wang W, Yin K, Sundback C, Wegst U, Jowett N. Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model. The Laryngoscope 2018, 128: e386-e392. PMID: 30098047, DOI: 10.1002/lary.27439.Peer-Reviewed Original ResearchConceptsHigh-throughput platformConduit performanceTissue processing stepsRobust axonal sproutingSciatic nerve transectionHigh throughputCryosection techniqueFluorescent reporter miceVivo mammalian modelsInterposition repairAxonal sproutingNerve transectionIsoflurane anesthesiaPeripheral neuronsAxonal ingrowthProcedure timeReporter miceNerve regenerationTransgenic miceVivo modelMiceMicroscopyVivo platformFluorescent proteinFluorescent microscopyLong-Term Outcomes of Free Gracilis Muscle Transfer for Smile Reanimation in Children
Greene J, Tavares J, Mohan S, Jowett N, Hadlock T. Long-Term Outcomes of Free Gracilis Muscle Transfer for Smile Reanimation in Children. The Journal Of Pediatrics 2018, 202: 279-284.e2. PMID: 30054167, DOI: 10.1016/j.jpeds.2018.06.043.Peer-Reviewed Original ResearchConceptsFree gracilis muscle transferFacial palsyGracilis muscle transferSmile excursionQuality of lifeMuscle transferPostoperative photographySmile reanimationFacial Clinimetric Evaluation (FaCE) surveyPatient-based instrumentLong-term outcomesCohort of childrenFacial nerve centerFacial symmetryPediatric patientsPostoperative qualityLife scoresTerm outcomesRetrospective analysisMassachusetts EyePalsySignificant improvementFacial impairmentPatientsFacial asymmetryOpioids and the Otolaryngologist: An Ambulatory Assessment
Mohan S, Bhattacharyya N. Opioids and the Otolaryngologist: An Ambulatory Assessment. Otolaryngology 2018, 159: 29-34. PMID: 29557264, DOI: 10.1177/0194599818765125.Peer-Reviewed Original ResearchConceptsOpioid prescriptionsOtolaryngology visitsOpioid prescribingCalendar trendsNational Ambulatory Medical Care SurveyAmbulatory Medical Care SurveyDesign Cross-sectional analysisOpioid medication prescribingOpioid prescription patternsChronic otitis mediaOpioid prescription ratesAmbulatory care settingsCross-sectional analysisOutpatient opioidsNational survey databasePrescription patternsNasal obstructionPrescription ratesMedication prescribingPostoperative careOtitis externaOtitis mediaCare SurveyOpioid epidemicCare settingsAssessment of Disease‐Specific and General Patient‐Reported Outcome Measures of Hearing Health
Mohan S, Corrales C, Yueh B, Shin J. Assessment of Disease‐Specific and General Patient‐Reported Outcome Measures of Hearing Health. Otolaryngology 2018, 158: 702-709. PMID: 29460681, DOI: 10.1177/0194599818757998.Peer-Reviewed Original ResearchConceptsPROMIS scoresTertiary care academic medical centerMental health summary scoresGlobal itemMental healthPhysical healthInner earProspective cohort dataDisease-specific assessmentsGeneral health statusHealth summary scoresComposite scoreItem scoresAcademic medical centerMean scoreChief complaintPROMIS instrumentsDisease-SpecificGeneral patientsHearing lossOutcome measuresMedical CenterMethods AdultsSummary scoresHealth status
2017
Modified approach for pediatric external cricopharyngeal myotomy
Mohan S, Bowe S, Hirner L, Zar-Kessler C, Hartnick C. Modified approach for pediatric external cricopharyngeal myotomy. International Journal Of Pediatric Otorhinolaryngology 2017, 105: 111-114. PMID: 29447795, DOI: 10.1016/j.ijporl.2017.12.019.Peer-Reviewed Original ResearchConceptsOpen cricopharyngeal myotomyCricopharyngeal myotomyCricopharyngeal achalasiaUpper esophageal sphincter relaxationPediatric cricopharyngeal achalasiaBotulinum toxin injectionEsophageal sphincter relaxationRecurrent laryngeal nerveBalloon dilationEsophageal perforationSphincter relaxationToxin injectionLaryngeal nerveOropharyngeal dysphagiaPosterior midlineImportant causeRisky procedureYoung malesAchalasiaMyotomyDysphagiaCricopharyngeusNervePathophysiologyAdjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity
Mohan S, Pai S, Bhattacharyya N. Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity. The Laryngoscope 2017, 127: 1334-1338. PMID: 28150306, PMCID: PMC7388729, DOI: 10.1002/lary.26443.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Squamous CellCarcinoma, VerrucousCross-Sectional StudiesDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedMouthMouth NeoplasmsNeoplasm Recurrence, LocalRadiotherapy, AdjuvantSEER ProgramSquamous Cell Carcinoma of Head and NeckTreatment OutcomeConceptsAdjuvant radiation therapyDisease-specific survivalSquamous cell carcinomaVerrucous carcinomaRadiation therapyOverall survivalOral cavityVC patientsWorse OSCarcinoma patientsImproved overall survivalEnd Results (SEER) databaseKaplan-Meier survivalAdjuvant radiotherapySCC patientsLocal recurrenceResults databaseT stagePositive marginsSCC casesCell carcinomaPatientsSurgeryCarcinomaDifferent biology
2016
SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Eytan D, Snow G, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers A, Hernandez L, Mitchell J, Annunziata C, Chen Z, Van Waes C. SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. Cancer Research 2016, 76: 5442-5454. PMID: 27469115, PMCID: PMC5026594, DOI: 10.1158/0008-5472.can-15-3317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBlotting, WesternCarcinoma, Squamous CellCell Line, TumorChemoradiotherapyDipeptidesFas-Associated Death Domain ProteinFemaleGene AmplificationGene Knockdown TechniquesHead and Neck NeoplasmsHumansImmunohistochemistryIndolesInhibitor of Apoptosis ProteinsMiceMice, Inbred BALB CMice, SCIDReal-Time Polymerase Chain ReactionSquamous Cell Carcinoma of Head and NeckTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaUbiquitin-Protein LigasesXenograft Model Antitumor AssaysConceptsSmac mimeticsCell deathNovel Smac mimeticsCaspase-dependent apoptosisExpression of FADDFrequent genomic amplificationCell cycle arrestBaculovirus inhibitorG2-M cell cycle arrestApoptosis repeatCancer Genome AtlasDeath domainIAP inhibitorsFunctional importanceSiRNA knockdownDNA fragmentationHNSCC cell linesFADDBirinapantGenomic amplificationGene transferGenome AtlasProtein markersComparison of tumorGenomic alterationsPapillary Thyroid Cancer in a Child with Progressive Transformation of Germinal Centers
Mohan S, DeNardo B, Stachurski D, Welch J, Groblewski J. Papillary Thyroid Cancer in a Child with Progressive Transformation of Germinal Centers. Case Reports In Otolaryngology 2016, 2016: 6469073. PMID: 27069706, PMCID: PMC4812356, DOI: 10.1155/2016/6469073.Peer-Reviewed Original ResearchNodular lymphocyte predominant Hodgkin lymphomaPapillary thyroid carcinomaPapillary thyroid cancerThyroid carcinomaThyroid cancerGerminal centersLymphocyte predominant Hodgkin lymphomaRadioactive iodine therapyCentral neck dissectionPredominant Hodgkin lymphomaRight parotid massFine-needle aspirationCervical lymphadenopathyFinal pathologyIodine therapyNeck lymphadenopathyTotal thyroidectomyNeck dissectionPersistent lymphadenopathySurgical managementMultiple biopsiesHodgkin's lymphomaUncommon conditionRisk factorsImmune surveillance
2015
MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma
Mohan S, Vander Broek R, Shah S, Eytan D, Pierce M, Carlson S, Coupar J, Zhang J, Cheng H, Chen Z, Van Waes C. MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research 2015, 21: 3946-3956. PMID: 25977343, PMCID: PMC4558307, DOI: 10.1158/1078-0432.ccr-14-3377.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBenzamidesCarcinoma, Squamous CellCell Line, TumorCell ProliferationCell SurvivalCell Transformation, NeoplasticCytokinesDiphenylamineDisease Models, AnimalDrug Resistance, NeoplasmDrug SynergismGene ExpressionGenes, ReporterHead and Neck NeoplasmsHumansInflammation MediatorsMitogen-Activated Protein Kinase KinasesMorpholinesNF-kappa BPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhosphorylationProtein Kinase InhibitorsSignal TransductionSquamous Cell Carcinoma of Head and NeckTOR Serine-Threonine KinasesTranscription Factor AP-1Transcriptional ActivationTriazinesXenograft Model Antitumor Assays