2000
The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA
Dunbar D, Chen A, Wormsley S, Baserga S. The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA. Nucleic Acids Research 2000, 28: 2855-2861. PMID: 10908346, PMCID: PMC102681, DOI: 10.1093/nar/28.15.2855.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacteriophage P1Base SequenceBlotting, SouthernChromosome MappingCloning, MolecularDNA Restriction EnzymesGenesMolecular Sequence DataMultigene FamilyPolymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, ProtozoanRNA, Small NucleolarTandem Repeat SequencesTranscription, GeneticTrypanosoma brucei brucei
1988
Detecting small mutations in expressed genes by a combination of S1 nuclease and RNase A
Atweh G, Baserga S, Brickner H. Detecting small mutations in expressed genes by a combination of S1 nuclease and RNase A. Nucleic Acids Research 1988, 16: 8709-8709. PMID: 2843823, PMCID: PMC338588, DOI: 10.1093/nar/16.17.8709.Peer-Reviewed Original ResearchNonsense mutations in the human beta-globin gene affect mRNA metabolism.
Baserga S, Benz E. Nonsense mutations in the human beta-globin gene affect mRNA metabolism. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 2056-2060. PMID: 3353367, PMCID: PMC279927, DOI: 10.1073/pnas.85.7.2056.Peer-Reviewed Original ResearchConceptsHeterologous transfection systemBeta-globin mRNABeta-globin geneNonsense mutationHuman beta-globin geneTransfection systemTranslation termination codonPeripheral blood cellsHuman beta-globin mRNATranslation termination mutationsMammalian mRNAsMRNA metabolismBeta 17Steady-state levelsTermination codonMRNA accumulationNormal levelsTypes of mutationsTermination mutationsBlood cellsMissense mutationsGenesHuman alphaMutationsZero-thalassemia