1992
Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.
Baserga S, Benz E. Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2935-2939. PMID: 1557399, PMCID: PMC48778, DOI: 10.1073/pnas.89.7.2935.Peer-Reviewed Original ResearchConceptsMRNA metabolismHeterologous transfection systemRNA polymerase IIHuman beta-globin geneMetabolism of mRNAAmber nonsense mutationsAnalysis of transcriptionAccumulation of mRNARNA expression studiesBeta-globin genePolymerase IIMRNA polyadenylationCytoplasmic stabilityMRNA stabilityExpression studiesPermanent cell linesProtein synthesisTransfection systemMediterranean populationsNonsense mutationSplicing accuracyMutationsDeficient accumulationCell linesMRNA
1990
Metabolism of Non‐Translatable Globin mRNAs Arising from Premature Translation Termination Codons
MAGNUS T, BASERGA S, STOLLE C, TAKESHITA K, BENZ E. Metabolism of Non‐Translatable Globin mRNAs Arising from Premature Translation Termination Codons. Annals Of The New York Academy Of Sciences 1990, 612: 55-66. PMID: 2291574, DOI: 10.1111/j.1749-6632.1990.tb24290.x.Peer-Reviewed Original Research
1988
Detecting small mutations in expressed genes by a combination of S1 nuclease and RNase A
Atweh G, Baserga S, Brickner H. Detecting small mutations in expressed genes by a combination of S1 nuclease and RNase A. Nucleic Acids Research 1988, 16: 8709-8709. PMID: 2843823, PMCID: PMC338588, DOI: 10.1093/nar/16.17.8709.Peer-Reviewed Original ResearchNonsense mutations in the human beta-globin gene affect mRNA metabolism.
Baserga S, Benz E. Nonsense mutations in the human beta-globin gene affect mRNA metabolism. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 2056-2060. PMID: 3353367, PMCID: PMC279927, DOI: 10.1073/pnas.85.7.2056.Peer-Reviewed Original ResearchConceptsHeterologous transfection systemBeta-globin mRNABeta-globin geneNonsense mutationHuman beta-globin geneTransfection systemTranslation termination codonPeripheral blood cellsHuman beta-globin mRNATranslation termination mutationsMammalian mRNAsMRNA metabolismBeta 17Steady-state levelsTermination codonMRNA accumulationNormal levelsTypes of mutationsTermination mutationsBlood cellsMissense mutationsGenesHuman alphaMutationsZero-thalassemia