2023
Evaluation of the SSTR2-targeted Radiopharmaceutical 177Lu-DOTATATE and SSTR2-specific 68Ga-DOTATATE PET as Imaging Biomarker in Patients with Intracranial Meningioma.
Kurz S, Zan E, Cordova C, Troxel A, Barbaro M, Silverman J, Snuderl M, Zagzag D, Kondziolka D, Golfinos J, Chi A, Sulman E. Evaluation of the SSTR2-targeted Radiopharmaceutical 177Lu-DOTATATE and SSTR2-specific 68Ga-DOTATATE PET as Imaging Biomarker in Patients with Intracranial Meningioma. Clinical Cancer Research 2023, 30: 680-686. PMID: 38048045, DOI: 10.1158/1078-0432.ccr-23-2533.Peer-Reviewed Original ResearchConceptsProgression-free survivalSomatostatin receptor type 2PFS-6Stable diseaseOverall survivalIntracranial meningiomasSingle-arm phase II clinical studyMedian progression-free survivalPhase II clinical studyImaging biomarkersCourse of radiationReceptor type 2Multicenter clinical trialMacdonald criteriaMedian OSRadiographic responseProgressive meningiomasTumor measurementsTumor resectionMedian agePrimary endpointRadiotherapeutic interventionSecondary endpointsMedical therapyAdult patients
2019
NIMG-09. NONINVASIVE PERFUSION IMAGING BIOMARKER OF MALIGNANT GENOTYPE IN ISOCITRATE DEHYDROGENASE MUTANT GLIOMAS
Mureb M, Jain R, Poisson L, Littig I, Neto L, Wu C, Ng V, Patel S, Patel S, Serrano J, Kurz S, Cahill D, Bendszus M, von Deimling A, Placantonakis D, Golfinos J, Kickingereder P, Snuderl M, Chi A. NIMG-09. NONINVASIVE PERFUSION IMAGING BIOMARKER OF MALIGNANT GENOTYPE IN ISOCITRATE DEHYDROGENASE MUTANT GLIOMAS. Neuro-Oncology 2019, 21: vi163-vi163. PMCID: PMC6847952, DOI: 10.1093/neuonc/noz175.681.Peer-Reviewed Original ResearchCDKN2A/B homozygous deletionCopy number variationsHomozygous deletionHigher rCBVGenomic alterationsRelative cerebral blood volumeImmediate postoperative settingHigh perfusion areaCopy number statusCerebral blood volumeNon-invasive imaging biomarkerInformed treatment decisionsMalignant genotypePostoperative settingIDHwt glioblastomasRCBVCDKN2A/BIDHmutCNV analysisAstrocytomaBlood volumeTreatment decisionsPerfusion areaImaging biomarkersDNA hypomethylation