GENE-16. CLINICALLY AGGRESSIVE MENINGIOMAS ARE CHARACTERIZED BY MUTATIONAL SIGNATURES ASSOCIATED WITH DEFECTIVE DNA REPAIR AND MUTATIONS IN CHROMATIN REMODELING GENES
Kurz S, Liechty B, Kelly S, Vasudevaraja V, Bledea R, Wu P, Serrano J, Katz L, Silverman J, Pacione D, Golfinos J, Chi A, Snuderl M. GENE-16. CLINICALLY AGGRESSIVE MENINGIOMAS ARE CHARACTERIZED BY MUTATIONAL SIGNATURES ASSOCIATED WITH DEFECTIVE DNA REPAIR AND MUTATIONS IN CHROMATIN REMODELING GENES. Neuro-Oncology 2018, 20: vi106-vi106. PMCID: PMC6216611, DOI: 10.1093/neuonc/noy148.442.Peer-Reviewed Original ResearchSingle nucleotide variantsChromatin remodeling genesCancer-associated genesDefective DNA repairChromatin remodelingAggressive meningiomasMutational signaturesDNA repairIncreased copy number variationDNA methylation array analysisSomatic mutationsRemodeling genesClinically aggressive meningiomasUnfavorable clinical courseAssociated with more aggressive behaviorCopy number variationsPattern of somatic mutationsWhole-exome sequencingMethylation array analysisDNA methylation phenotypeMedian PFSNucleotide variantsAggressive tumorsClinical courseRecurrence rate