Immunologic Status Evaluated By the Absolute Lymphocyte/Monocyte Ratio Provides a Powerful Prognostic Tool for Newly Diagnosed Multiple Myeloma
Malek E, Dosani T, Pinto R, Covut F, Akabane H, Driscoll J, De Lima M. Immunologic Status Evaluated By the Absolute Lymphocyte/Monocyte Ratio Provides a Powerful Prognostic Tool for Newly Diagnosed Multiple Myeloma. Blood 2016, 128: 1862. DOI: 10.1182/blood.v128.22.1862.1862.Peer-Reviewed Original ResearchALC/AMC ratioLow ALC/AMC ratioProgression-free survivalAbsolute lymphocyte countAbsolute monocyte countTumor-associated macrophagesHigh absolute monocyte countLow absolute lymphocyte countHost immune statusOverall survivalPrognostic factorsMM patientsHost immune systemPrognostic significanceMultivariate analysisImmune statusSurrogate markerSuperior median progression-free survivalImmune systemPredictors of PFSLymphocyte/monocyte ratioMedian progression-free survivalLonger progression-free survivalDifferent progression-free survivalImmunosuppressive tumor-associated macrophages