2024
Detection of hepatocellular carcinoma methylation markers in salivary DNA
Mezzacappa C, Wang Z, Lu L, Risch H, Taddei T, Yu H. Detection of hepatocellular carcinoma methylation markers in salivary DNA. Bioscience Reports 2024, 44: bsr20232063. PMID: 38457142, PMCID: PMC10958141, DOI: 10.1042/bsr20232063.Peer-Reviewed Original ResearchHepatocellular carcinoma screeningCase patientsHepatocellular carcinomaControl subjectsDiagnosis of hepatocellular carcinomaAssociated with hepatocellular carcinomaScreening testSalivary DNASaliva-based testCpG sitesStudy of risk factorsSalivary DNA methylationDNA methylationViral hepatitisCirculating DNAAlterations to DNA methylationRisk factorsMethylation markersPatientsRegulation of cell cycle progressionBlood samplesCell cycle progressionAffected individualsAlternative to blood samplingMultiple comparisons
2013
Serum‐mediated transgenerational effects on sperm: Evidence for lamarckian inheritance?
Seki Y, Groszmann R, Iwakiri Y, Taddei T. Serum‐mediated transgenerational effects on sperm: Evidence for lamarckian inheritance? Hepatology 2013, 57: 1663-1665. PMID: 23568276, DOI: 10.1002/hep.26240.Peer-Reviewed Original ResearchPeroxisome proliferator-activated receptor gLiver fibrosisCells exposed to conditioned mediumRemodeling of DNA methylationLiver damageMild liver fibrosisTrimethylation of histone H3Histone variant H2A.ZHepatic wound healingWound healingNaive ratsCultured ratSevere fibrosisSperm chromatinHepatic insultProfibrogenic factorsSerum transferVariant H2A.ZMale ratsDNA methylationConditioned mediumHistone H3Histone acetylationTGF-b1Epigenetic signatures