2018
Primary Liver Tumors Other than Hepatocellular Carcinoma: Clinical and Molecular Pearls
Costantino A, Taddei T. Primary Liver Tumors Other than Hepatocellular Carcinoma: Clinical and Molecular Pearls. Current Hepatology Reports 2018, 17: 412-424. DOI: 10.1007/s11901-018-0426-6.Peer-Reviewed Original ResearchHepatocellular carcinomaRare tumorRare liver tumorGreater survival benefitRare malignant tumorRecent FindingsRecent literatureMetastatic diseaseSurgical resectionSurvival benefitAtypical presentationTherapeutic optionsPrimary liverNovel therapiesDifferential diagnosisMalignant tumorsFibrolamellar HCCLiver tumorsTherapeutic interventionsTumor typesTumor biologyCarcinomaTherapeutic possibilitiesTumorsMolecular pathwaysOngoing studies
2013
Notching up on the cellular origins of intrahepatic cholangiocarcinoma
Sirica A, Groszmann R, Iwakiri Y, Taddei T. Notching up on the cellular origins of intrahepatic cholangiocarcinoma. Hepatology 2013, 57: 1668-1671. PMID: 23390051, DOI: 10.1002/hep.26313.Peer-Reviewed Original ResearchOrigin of intrahepatic cholangiocarcinomaBiliary lineage cellsLiver progenitor cellsBiliary epithelial cellsIntrahepatic cholangiocarcinomaCell type-specific reportersMouse modelLineage cellsCellular originMouse model of intrahepatic cholangiocarcinomaPrimary liver tumorsActivated NotchDevelopment of effective therapiesNotch activationAkt signalingLiver cell typesCell typesRefractory diseasePrimary malignancyPoor prognosisViral hepatitisLiver tumorsMalignant tumorsEffective therapyProgenitor cells