2013
Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence
Bosch J, Groszmann R, Iwakiri Y, Taddei T. Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence. Hepatology 2013, 57: 1665-1667. PMID: 23359118, DOI: 10.1002/hep.26279.Peer-Reviewed Original ResearchCarvedilol groupSevere adverse eventsVariceal bleedingAdverse eventsVariceal rebleedingRecurrent bleedingI groupControl of acute esophageal variceal bleedingPrevention of gastroesophageal variceal rebleedingPreventing recurrent variceal bleedingAcute esophageal variceal bleedingDecrease portal pressureRecurrent upper gastrointestinal bleedingRecurrent variceal bleedingEsophageal variceal bleedingUpper gastrointestinal bleedingMedian followEsophageal varicesGastric varicesPortal pressureGastrointestinal bleedingIsosorbide mononitrateBleedingCarvedilolPatients
2012
PPARα activation in portal hypertension
Liu H, Lee S, Groszmann R, Iwakiri Y, Taddei T. PPARα activation in portal hypertension. Hepatology 2012, 56: 1993-1995. PMID: 23115009, DOI: 10.1002/hep.26045.Peer-Reviewed Original ResearchHepatic endothelial cellsHepatic endothelial dysfunctionPortal blood flowPortal hypertensionCyclo-oxygenase-1PPARa activatorPortal pressureSirius Red staining of liver sectionsEndothelial dysfunctionHepatic fibrosisVasodilatory response to acetylcholineRats treated with fenofibrateStaining of liver sectionsResponse to acetylcholineTreated with vehicleDevelopment of cirrhosisSmooth muscle actinCollagen I mRNA expressionNitric oxideCyclo-oxygenase-1 expressionAcetylcholine (AChCirrhotic rat liversOral fenofibrateCirrhotic ratsCGMP levels