Serum‐mediated transgenerational effects on sperm: Evidence for lamarckian inheritance?
Seki Y, Groszmann R, Iwakiri Y, Taddei T. Serum‐mediated transgenerational effects on sperm: Evidence for lamarckian inheritance? Hepatology 2013, 57: 1663-1665. PMID: 23568276, DOI: 10.1002/hep.26240.Peer-Reviewed Original ResearchPeroxisome proliferator-activated receptor gLiver fibrosisCells exposed to conditioned mediumRemodeling of DNA methylationLiver damageMild liver fibrosisTrimethylation of histone H3Histone variant H2A.ZHepatic wound healingWound healingNaive ratsCultured ratSevere fibrosisSperm chromatinHepatic insultProfibrogenic factorsSerum transferVariant H2A.ZMale ratsDNA methylationConditioned mediumHistone H3Histone acetylationTGF-b1Epigenetic signatures