2017
Beyond Anthracyclines: Preemptive Management of Cardiovascular Toxicity in the Era of Targeted Agents for Hematologic Malignancies
Sethi TK, Basdag B, Bhatia N, Moslehi J, Reddy NM. Beyond Anthracyclines: Preemptive Management of Cardiovascular Toxicity in the Era of Targeted Agents for Hematologic Malignancies. Current Hematologic Malignancy Reports 2017, 12: 257-267. PMID: 28233150, DOI: 10.1007/s11899-017-0369-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular side effectsHematologic malignanciesSide effectsUnique side effect profileCardiovascular adverse eventsSide effect profileLong-term administrationNon-Hodgkin lymphomaChronic myeloid leukemiaTyrosine kinase inhibitorsYears of ageOrgan-specific toxicityAdverse eventsFace of treatmentTargeted agentsEffect profilePatient populationCardiovascular toxicityMyeloid leukemiaNew agentsPreemptive managementMalignancyPrior exposureKinase inhibitorsProteasome inhibitors
2015
Risk Factors for Cardiac Toxicities Associated with Proteasome Inhibitor Chemotherapy during Treatment of Multiple Myeloma
Chen J, Lenihan D, Phillips S, Jagasia M, Goodman S, Kassim A, Lacy S, McDonagh K, Moslehi J, Sethi T, Slosky D, Ukaegbu O, Cornell R. Risk Factors for Cardiac Toxicities Associated with Proteasome Inhibitor Chemotherapy during Treatment of Multiple Myeloma. Blood 2015, 126: 5363. DOI: 10.1182/blood.v126.23.5363.5363.Peer-Reviewed Original ResearchCardiac adverse eventsIndependent risk factorCardiac eventsCumulative incidenceRisk factorsMultiple myelomaPrior historyAdverse eventsAntithrombotic therapyPI therapyMedian durationPrior linesMore patientsMale genderAtherosclerotic cardiovascular disease riskC groupCardiac Toxicity AssociatedMedian prior linesLipid-lowering medicationsB groupCardiovascular disease riskStem cell transplantationCourse of treatmentProteasome inhibitor bortezomibIncidence of PI