Correlation of Toll-like Receptor (TLR) and PD-1 Pathways in Central Nervous System Lymphoma: A Clinicopathological Study on Outcomes
Sethi T, Kovach A, Rubinstein S, Lee L, Wang Y, Morgan D, Greer J, Vnencak-Jones C, Reddy N. Correlation of Toll-like Receptor (TLR) and PD-1 Pathways in Central Nervous System Lymphoma: A Clinicopathological Study on Outcomes. Blood 2016, 128: 929. DOI: 10.1182/blood.v128.22.929.929.Peer-Reviewed Original ResearchCentral nervous system lymphomaPD-1/PD-L1 expressionProgression-free survivalPD-L1 expressionToll-like receptorsPD-1/PD-L1Diffuse large B-cell lymphomaPD-1/ PDNervous system lymphomaPD-L1Overall survivalMYD88 mutationsPD-1System lymphomaStimulation of TLRsCancer cell survivalHigh-dose methotrexate-based therapySystemic diffuse large B-cell lymphomaCo-expressing PD-1Median progression-free survivalPrior solid organ transplantMyeloid differentiation primary response protein 88Adaptor proteinAdvisory CommitteeB-cell receptor pathway