2018
Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation
Aghighi M, Theruvath AJ, Pareek A, Pisani LL, Alford R, Muehe AM, Sethi TK, Holdsworth SJ, Hazard FK, Gratzinger D, Luna-Fineman S, Advani R, Spunt SL, Daldrup-Link HE. Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation. Clinical Cancer Research 2018, 24: 4110-4118. PMID: 29764855, PMCID: PMC6125171, DOI: 10.1158/1078-0432.ccr-18-0673.Peer-Reviewed Original ResearchConceptsBone sarcomasClinical trialsFerumoxytol-enhanced MRIImmune-targeted therapiesProspective clinical trialsYoung adult patientsDensity of CD68Biopsy/resectionClin Cancer ResTumor biopsy/resectionInstitutional review boardNoninvasive imaging techniquesPrecontrast scansTAM densityAdult patientsPilot patientsPediatric patientsPostcontrast MRIPostcontrast scansCancer immunotherapyMacrophage stainingTumor responseMRI 24Tumor groupMalignant tumors
2016
Three-dimensional Radiologic Assessment of Chemotherapy Response in Ewing Sarcoma Can Be Used to Predict Clinical Outcome.
Aghighi M, Boe J, Rosenberg J, Von Eyben R, Gawande RS, Petit P, Sethi TK, Sharib J, Marina NM, DuBois SG, Daldrup-Link HE. Three-dimensional Radiologic Assessment of Chemotherapy Response in Ewing Sarcoma Can Be Used to Predict Clinical Outcome. Radiology 2016, 280: 905-15. PMID: 26982677, PMCID: PMC5006736, DOI: 10.1148/radiol.2016151301.Peer-Reviewed Original ResearchConceptsBasis of RECISTWorld Health OrganizationTherapeutic responseStandard of referenceOverall survivalClinical outcomesTumor responseTumor measurementsThree-dimensional tumor measurementsResponse Evaluation CriteriaPrimary tumor sizeLog-rank testKaplan-Meier plotsTherapeutic response assessmentInstitutional review boardTumor volume measurementsVolume measurementsPatient survivalRetrospective studyCox regressionTumor sizeGroup criteriaBland-Altman analysisEwing's sarcomaMedical Center