Histology-Specific Uses of Tyrosine Kinase Inhibitors in Non-gastrointestinal Stromal Tumor Sarcomas
Sethi TK, Keedy VL. Histology-Specific Uses of Tyrosine Kinase Inhibitors in Non-gastrointestinal Stromal Tumor Sarcomas. Current Treatment Options In Oncology 2016, 17: 11. PMID: 26931561, DOI: 10.1007/s11864-015-0382-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntineoplastic AgentsBone NeoplasmsGastrointestinal Stromal TumorsHumansProtein Kinase InhibitorsProtein-Tyrosine KinasesReceptor Protein-Tyrosine KinasesSarcomaSignal TransductionConceptsTyrosine kinase inhibitorsTreatment optionsEfficacy of TKIsMulti-targeted tyrosine kinase inhibitorAlveolar soft part sarcomaKinase inhibitorsNon-GIST sarcomasSpectrum of sarcomasFirst-line treatmentEfficacy of imatinibSoft tissue sarcomasImportant clinical questionsPoor response ratesSoft part sarcomaTarget-specific agentsDermatofibrosarcoma protruberansUnresectable diseaseAdvanced sarcomasRECIST criteriaBone sarcomasClinical efficacyTissue sarcomasRare tumorPreclinical dataChemotherapeutic options