2023
Integrative deep learning analysis improves colon adenocarcinoma patient stratification at risk for mortality
Zhou J, pour A, Deirawan H, Daaboul F, Aung T, Beydoun R, Ahmed F, Chuang J. Integrative deep learning analysis improves colon adenocarcinoma patient stratification at risk for mortality. EBioMedicine 2023, 94: 104726. PMID: 37499603, PMCID: PMC10388166, DOI: 10.1016/j.ebiom.2023.104726.Peer-Reviewed Original ResearchConceptsModerate-risk patientsClinical variablesPatient stratificationOverall survivalAdenocarcinoma patientsTCGA-COADLow-risk patientsColorectal cancer patientsEnrollment of patientsRectal adenocarcinoma patientsRisk of mortalityColon adenocarcinoma patientsLow immune infiltrationNational Cancer InstituteMutation signaturesNumber of deathsCancer Genome AtlasColorectal cancerPathological featuresCancer patientsImmune infiltrationImproved stratificationClinical trialsPatient riskCancer Institute
2021
Quantitative Assessment of CD200 and CD200R Expression in Lung Cancer
Vathiotis IA, MacNeil T, Zugazagoitia J, Syrigos KN, Aung TN, Gruver AM, Vaillancourt P, Hughes I, Hinton S, Driscoll K, Rimm DL. Quantitative Assessment of CD200 and CD200R Expression in Lung Cancer. Cancers 2021, 13: 1024. PMID: 33804482, PMCID: PMC7957629, DOI: 10.3390/cancers13051024.Peer-Reviewed Original ResearchLung cancer patientsCD200R expressionClinicopathologic characteristicsPD-L1Cancer patientsLung cancerImmune cellsLarge-cell neuroendocrine carcinoma patientsMutation statusNon-small cell lung cancer patientsCell lung cancer patientsQuantitative immunofluorescenceMultiplexed quantitative immunofluorescenceNeuroendocrine carcinoma patientsExpression of CD200Lung cancer cohortTumor cell stainingLCNEC patientsOverall survivalCarcinoma patientsImmune checkpointsImmune therapyTumor positivitySquamous differentiationCancer cohort