2019
Effect of Compound Kushen Injection, a Natural Compound Mixture, and Its Identified Chemical Components on Migration and Invasion of Colon, Brain, and Breast Cancer Cell Lines
Nourmohammadi S, Aung TN, Cui J, Pei JV, De Ieso ML, Harata-Lee Y, Qu Z, Adelson DL, Yool AJ. Effect of Compound Kushen Injection, a Natural Compound Mixture, and Its Identified Chemical Components on Migration and Invasion of Colon, Brain, and Breast Cancer Cell Lines. Frontiers In Oncology 2019, 9: 314. PMID: 31106149, PMCID: PMC6498862, DOI: 10.3389/fonc.2019.00314.Peer-Reviewed Original ResearchCompound Kushen InjectionCell linesFocal adhesion genesBreast cancer cell linesCancer cell linesCell imagingActin cytoskeletalHuman embryonic kidneyTranscriptomic analysisAdhesion genesMDA-MB-231 cellsCell cycleBreast cancerInvasion of colonKushen InjectionEmbryonic kidneyCell migrationExtracellular matrixTranswell invasionNatural compound mixturesCKI treatmentHEK-293Cancer migrationNon-cancerous controlsCancer metastasis
2017
Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action
Aung TN, Qu Z, Kortschak RD, Adelson DL. Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action. International Journal Of Molecular Sciences 2017, 18: 656. PMID: 28304343, PMCID: PMC5372668, DOI: 10.3390/ijms18030656.Peer-Reviewed Original ResearchConceptsAnti-cancer agentsNatural compound mixturesTherapeutic benefitCancer progressionCancer cellsSynergistic therapeutic benefitsPotential molecular targetsPositive therapeutic benefitsAberrant apoptotic pathwaysClinical efficacyTreatment of cancerAdverse reactionsCancer managementMerit further investigationMultiple specific targetsDrug resistanceCancerGenetic abnormalitiesEffective dosageLimited evidenceMolecular targetsScientific evidenceApoptotic mechanismsFurther investigationProgression