2020
Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis
Zhan W, Akshintala V, Greer PJ, Greer JB, Alkaade S, Anderson MA, Muniraj T, Papachristou GI, Sandhu BS, Slivka A, Wilcox CM, Bellin MD, Singh VK, Yadav D, Brand RE, Whitcomb DC, Group F. Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis. Pancreatology 2020, 20: 1368-1378. PMID: 32967795, DOI: 10.1016/j.pan.2020.08.025.Peer-Reviewed Original ResearchConceptsSerum trypsinogen levelsChronic pancreatitisTrypsinogen levelsAcinar cell functionCP patientsParenchymal lossCell functionComplex inflammatory disorderExocrine pancreatic insufficiencyCT-based criteriaNAPS2 studySerum trypsinogenAcinar cell lossSurgical resectionFinal cohortInflammatory cellsInflammatory disordersControl subjectsSeverity scoreClinical managementPancreatic insufficiencyStellate cellsNormal rangeCell lossIslet cells
2018
Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry
Phillips AE, LaRusch J, Greer P, Abberbock J, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Brand RE, Conwell D, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, Lewis M, Money ME, Muniraj T, Sandhu BS, Sherman S, Singh VK, Slivka A, Tang G, Wilcox CM, Whitcomb DC, Yadav D. Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry. Pancreatology 2018, 18: 528-535. PMID: 29859674, PMCID: PMC8715541, DOI: 10.1016/j.pan.2018.05.482.Peer-Reviewed Original ResearchPathogenic genetic variantsRecurrent acute pancreatitisAA patientsAA subjectsGenetic variantsAfrican ancestryGenetic susceptibility factorsComplex risk factorsAfrican American subjectsNAPS2 studyAlcohol etiologyAcute pancreatitisChronic pancreatitisEA patientsCP subjectsRisk factorsAA casesPatientsPancreatitisSusceptibility factorsPrevalenceFurther studiesEA subjectsStructured questionnaireSPINK1
2017
Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group
Conwell DL, Banks PA, Sandhu BS, Sherman S, Al-Kaade S, Gardner TB, Anderson MA, Wilcox CM, Lewis MD, Muniraj T, Forsmark CE, Cote GA, Guda NM, Tian Y, Romagnuolo J, Wisniewski SR, Brand R, Gelrud A, Slivka A, Whitcomb DC, Yadav D. Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. Digestive Diseases And Sciences 2017, 62: 2133-2140. PMID: 28600657, PMCID: PMC6040886, DOI: 10.1007/s10620-017-4621-z.Peer-Reviewed Original ResearchConceptsRisk factorsIdiopathic etiologyEpidemiologic trendsChronic pancreatitis patientsRecent epidemiologic trendsMultiple risk factorsCurrent epidemiologic trendsNAPS2 studyAlcohol etiologyCP patientsYounger patientsChronic pancreatitisCommon etiologyPancreatitis patientsMean ageConclusionOur dataUS CentersStudy groupEtiologyObjectivesOur aimPatientsGenetic etiologySmokingDemographic factorsValidation studyQuality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities
Machicado JD, Amann ST, Anderson MA, Abberbock J, Sherman S, Conwell DL, Cote GA, Singh VK, Lewis MD, Alkaade S, Sandhu BS, Guda NM, Muniraj T, Tang G, Baillie J, Brand RE, Gardner TB, Gelrud A, Forsmark CE, Banks PA, Slivka A, Wilcox CM, Whitcomb DC, Yadav D. Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities. The American Journal Of Gastroenterology 2017, 112: 633. PMID: 28244497, PMCID: PMC5828017, DOI: 10.1038/ajg.2017.42.Peer-Reviewed Original ResearchConceptsQuality of lifeMild-moderate painCurrent smokingChronic pancreatitisMCS scoresConstant painCP patientsSevere painShort Form-12 (SF-12) surveyMental component summary scoresConstant severe painComponent summary scoresMultivariable linear regression modelsAssociated co morbiditiesIndependent effectsFinal multivariable modelNAPS2 studySignificant independent effectDisease durationCo morbiditiesMean PCSIndependent predictorsMultivariable analysisPancreatic surgeryPCS scores