2021
Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study
Yadav D, Whitcomb D, Tang G, Slivka A, Bellin M, Consortium N, AlKaade S, Amann S, Anderson M, Banks P, Conwell D, Brand R, Cote G, Romagnuolo J, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Sandhu B, Sherman S, Singh V, Wilcox C. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study. Clinical Gastroenterology And Hepatology 2021, 21: 226-228.e1. PMID: 34793964, DOI: 10.1016/j.cgh.2021.11.011.Peer-Reviewed Original ResearchConceptsChronic pancreatitisCytokine-induced beta-cell dysfunctionPancreatogenic diabetes mellitusPrimary pathophysiologic defectType 3c diabetesSubset of patientsBeta-cell dysfunctionRecurrent AcuteGlucose intoleranceDiabetes mellitusPathophysiologic defectsFibrotic changesInsulin deficiencyCell dysfunctionExocrine pancreasPilot studyPancreatitisMellitusAcuteDiabetesInflammationPatientsDysfunctionInjuryPancreas
2017
Autoimmune pancreatitis: an update
Muniraj T, Sah R, Chari S. Autoimmune pancreatitis: an update. 2017, 152-160. DOI: 10.1002/9781118924907.ch12d.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsType 1 autoimmune pancreatitisType 2 autoimmune pancreatitisAutoimmune pancreatitisGranulocyte epithelial lesionsAbundant IgG4-positive plasma cellsIgG4-positive plasma cellsLymphoplasmacytic inflammatory infiltrateCommon clinical presentationDistinct histopathologic featuresOral steroidsObstructive jaundiceInflammatory infiltrateInflammatory infiltrationClinical presentationHistopathologic featuresStandard treatmentEpithelial lesionsPancreatic enlargementPlasma cellsDistinct subtypesType 1Concise updatePancreatitisPancreasRemission