2020
Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort
Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, LaRusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, Singh VK, Yadav D, Whitcomb DC. Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort. Journal Of Gastroenterology 2020, 55: 1000-1009. PMID: 32681239, PMCID: PMC9124361, DOI: 10.1007/s00535-020-01703-w.Peer-Reviewed Original ResearchConceptsConstant severe painRecurrent acute pancreatitisChronic pancreatitisDepression-associated genesCP patientsPain severityAntidepressant usePancreatitis patientsPain experienceProspective randomized trialsAntidepressant medication usePattern of painCase report formsChronic opioidsIslet autotransplantationAntidepressant therapyTotal pancreatectomyMedication usePain managementRandomized trialsCounseling patientsRetrospective studyAcute pancreatitisClinical trialsMajor depression
2018
Nutrition and Inflammatory Biomarkers in Chronic Pancreatitis Patients
Greer JB, Greer P, Sandhu BS, Alkaade S, Wilcox CM, Anderson MA, Sherman S, Gardner TB, Lewis MD, Guda NM, Muniraj T, Conwell D, Cote GA, Forsmark CE, Banks PA, Tang G, Stello K, Gelrud A, Brand RE, Slivka A, Whitcomb DC, Yadav D. Nutrition and Inflammatory Biomarkers in Chronic Pancreatitis Patients. Nutrition In Clinical Practice 2018, 34: 387-399. PMID: 30101991, PMCID: PMC6642676, DOI: 10.1002/ncp.10186.Peer-Reviewed Original ResearchConceptsC-reactive proteinCP patientsChronic pancreatitis patientsSerum prealbuminVitamin APancreatitis patientsVitamin supplementsHigher C-reactive proteinPancreatic enzyme replacement therapyInflammatory marker levelsPancreatic enzyme replacementSubset of patientsBody mass indexHigher serum levelsBone metabolism biomarkersTumor necrosis factorEnzyme replacement therapyLow levelsComorbid diabetesInflammatory biomarkersDiabetes mellitusSerum levelsMass indexPrimary etiologyReplacement therapy
2017
Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group
Conwell DL, Banks PA, Sandhu BS, Sherman S, Al-Kaade S, Gardner TB, Anderson MA, Wilcox CM, Lewis MD, Muniraj T, Forsmark CE, Cote GA, Guda NM, Tian Y, Romagnuolo J, Wisniewski SR, Brand R, Gelrud A, Slivka A, Whitcomb DC, Yadav D. Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. Digestive Diseases And Sciences 2017, 62: 2133-2140. PMID: 28600657, PMCID: PMC6040886, DOI: 10.1007/s10620-017-4621-z.Peer-Reviewed Original ResearchConceptsRisk factorsIdiopathic etiologyEpidemiologic trendsChronic pancreatitis patientsRecent epidemiologic trendsMultiple risk factorsCurrent epidemiologic trendsNAPS2 studyAlcohol etiologyCP patientsYounger patientsChronic pancreatitisCommon etiologyPancreatitis patientsMean ageConclusionOur dataUS CentersStudy groupEtiologyObjectivesOur aimPatientsGenetic etiologySmokingDemographic factorsValidation study
2011
Are Catechol-O-Methyl Transferase (COMT) Gene Polymorphisms Associated With Visceral Pain? – A Study in a Large Cohort of Chronic Pancreatitis (CP) Patients
Muniraj T, Yadav D, LaRusch J, Anderson M, Lyons J, O'Connell M, Brand R, Whitcomb D. Are Catechol-O-Methyl Transferase (COMT) Gene Polymorphisms Associated With Visceral Pain? – A Study in a Large Cohort of Chronic Pancreatitis (CP) Patients. Gastroenterology 2011, 140: s-857. DOI: 10.1016/s0016-5085(11)63559-2.Peer-Reviewed Original Research