2024
Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}
Wilcox C, Bang J, Buxbaum J, Gardner T, Hawes R, Kedia P, Mardini S, Muniraj T, Navaneethan U, Oza V, Tarnasky P, Thakkar S, Waxman I, Varadarajulu S. Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}. Trials 2024, 25: 676. PMID: 39396987, PMCID: PMC11472533, DOI: 10.1186/s13063-024-08478-y.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAutonomic Nerve BlockCeliac PlexusEndosonographyHumansMulticenter Studies as TopicNerve BlockPain MeasurementPalliative CarePancreatitis, ChronicProspective StudiesRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsCeliac plexus blockAbdominal painChronic pancreatitisVisual analog scalePlexus blockSham-controlled trialRandomized sham-controlled trialEndoscopic ultrasound-guided celiac plexus blockEffectiveness of endoscopic ultrasoundBrief Pain Inventory Short FormDocumented chronic pancreatitisPainful chronic pancreatitisPalliation of painTime of EUSTreatment of abdominal painPain scoresBPI-SFSteroid combinationsAnalog scaleEndoscopic ultrasoundProspective studyCeliac plexusRandomized trialsShort formPancreatitis
2021
Healthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy
McCarty TR, Chouairi F, Hathorn KE, Sharma P, Muniraj T, Thompson CC. Healthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy. Journal Of Gastrointestinal Surgery 2021, 25: 880-886. PMID: 33629232, DOI: 10.1007/s11605-021-04959-6.Peer-Reviewed Original ResearchConceptsLength of stayCharlson Comorbidity IndexPercutaneous cholecystostomyAcute cholecystitisRace/ethnicityU.S. Nationwide Inpatient Sample (NIS) databaseNationwide Inpatient Sample databaseAsian race/ethnicityHealthcare-related factorsHigher CCI scoresMedicare payer statusGood surgical candidatesMajority of patientsMultivariable logistic regressionUrban hospital locationUrban teaching hospitalSocioeconomic factorsCCI scoreComorbidity indexSurgical candidatesPayer statusMale genderHospital costsTeaching hospitalTreatment strategiesEvaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis
Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis. Surgical Endoscopy 2021, 36: 274-281. PMID: 33481109, DOI: 10.1007/s00464-020-08272-2.Peer-Reviewed Original ResearchConceptsSame-admission cholecystectomyAcute gallstone pancreatitisEndoscopic retrograde cholangiopancreatographyCharlson Comorbidity IndexGallstone pancreatitisRetrograde cholangiopancreatographyU.S. Nationwide Inpatient Sample (NIS) databaseHigher Charlson comorbidity indexNationwide Inpatient Sample databaseMedicare payer statusUrban-teaching hospitalsMajority of patientsMultivariable logistic regressionRace/ethnicitySocio-demographic factorsHospital mortalityComorbidity indexHospital stayPayer statusSurgical managementHospitalization costsResultsA totalBlack raceTreatment strategiesFemale gender
2020
AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis
Hirano I, Chan E, Rank M, Sharaf R, Stollman N, Stukus D, Wang K, Greenhawt M, Falck-Ytter Y, Chachu K, Day L, Lebwohl B, Muniraj T, Patel A, Peery A, Shah R, Singh H, Singh S, Spechler S, Sultan S, Su G, Thrift A, Weiss J, Weizman A, Bernstein J, Dinakar C, Hirano I, Falck-Ytter Y, Rank M, Stollman N, Wang K, Stukus D, Greenhawt M, Sharaf R, Chan E, Furuta G, Dellon E, Spergel J, Aceves S, Greenhawt M, Falck-Ytter Y, Rank M, Sharaf R. AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Annals Of Allergy Asthma & Immunology 2020, 124: 416-423. PMID: 32336462, PMCID: PMC8135034, DOI: 10.1016/j.anai.2020.03.020.Peer-Reviewed Original ResearchAGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis
Hirano I, Chan E, Rank M, Sharaf R, Stollman N, Stukus D, Wang K, Greenhawt M, Falck-Ytter Y, Chachu K, Day L, Lebwohl B, Muniraj T, Patel A, Peery A, Shah R, Singh H, Singh S, Spechler S, Sultan S, Su G, Thrift A, Weiss J, Weizman A, Bernstein J, Dinakar C, Golden D, Khan D, Lieberman J, Oppenheimer J, Shaker M, Wallace D, Wang J, Hirano I, Falck-Ytter Y, Rank M, Stollman N, Wang K, Stukus D, Greenhawt M, Sharaf R, Chan E, Furuta G, Dellon E, Spergel J, Aceves S, Greenhawt M, Falck-Ytter Y, Rank M, Sharaf R. AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis. Gastroenterology 2020, 158: 1776-1786. PMID: 32359562, PMCID: PMC9473154, DOI: 10.1053/j.gastro.2020.02.038.Peer-Reviewed Original ResearchTechnical Review on the Management of Eosinophilic Esophagitis: A Report From the AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters
Rank M, Sharaf R, Furuta G, Aceves S, Greenhawt M, Spergel J, Falck-Ytter Y, Dellon E, Institute A, Chachu K, Day L, Lebwohl B, Muniraj T, Patel A, Peery A, Shah R, Singh H, Singh S, Spechler S, Sultan S, Su G, Thrift A, Weiss J, Weizman A, collaborators J, Bernstein J, Dinakar C, Golden D, Khan D, Lieberman J, Oppenheimer J, Shaker M, Stukus D, Wallace D, Wang J. Technical Review on the Management of Eosinophilic Esophagitis: A Report From the AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters. Gastroenterology 2020, 158: 1789-1810.e15. PMID: 32359563, PMCID: PMC9473155, DOI: 10.1053/j.gastro.2020.02.039.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAdultAdvisory CommitteesAge FactorsAllergy and ImmunologyChildDilatationEosinophilic EsophagitisEosinophilsEsophagoscopyEvidence-Based MedicineFood HypersensitivityFood, FormulatedGastroenterologyGlucocorticoidsHumansProton Pump InhibitorsSocieties, MedicalTreatment OutcomeUnited StatesConceptsShort-term treatment periodEsophageal eosinophil countsHigh-power fieldLow certaintyTopical glucocorticosteroidsModerate certaintyEosinophilic esophagitisEosinophil countTreatment periodPractice parametersAmerican Gastroenterological Association InstituteAnti-IgE therapyAnti-TNF therapyChronic inflammatory conditionsProton pump inhibitorsJoint Task ForceDiet eliminationDietary eliminationElimination dietEoE managementEsophageal eosinophiliaMaintenance therapyRecommendations AssessmentElemental dietEsophageal dilationAGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis
Feuerstein J, Isaacs K, Schneider Y, Siddique S, Falck-Ytter Y, Singh S, Chachu K, Day L, Lebwohl B, Muniraj T, Patel A, Peery A, Shah R, Sultan S, Singh H, Singh S, Spechler S, Su G, Thrift A, Weiss J, Weizman A, Feuerstein J, Singh S, Isaacs K, Schneider Y, Falck-Ytter Y, Siddique S, Allegretti J, Terdiman J, Singh S, Siddique S. AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis. Gastroenterology 2020, 158: 1450-1461. PMID: 31945371, PMCID: PMC7175923, DOI: 10.1053/j.gastro.2020.01.006.Peer-Reviewed Original ResearchAdultBiological ProductsClinical Decision-MakingClinical Trials as TopicColectomyColitis, UlcerativeColonColonoscopyDrug Therapy, CombinationEvidence-Based MedicineGastroenterologyGlucocorticoidsHumansImmunologic FactorsIntestinal MucosaSeverity of Illness IndexSocieties, MedicalTreatment OutcomeUnited StatesEndoscopic Retrograde Cholangiopancreatography: Deciphering the Black and White
Mahalingam S, Langdon J, Muniraj T, Do A, Guo Y, Spektor M, Mathur M. Endoscopic Retrograde Cholangiopancreatography: Deciphering the Black and White. Current Problems In Diagnostic Radiology 2020, 50: 74-84. PMID: 32063296, DOI: 10.1067/j.cpradiol.2020.01.001.Peer-Reviewed Original Research
2018
AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis
Ko C, Singh S, Feuerstein J, Falck-Ytter C, Falck-Ytter Y, Cross R, Committee A, Crockett S, Falck-Ytter Y, Feuerstein J, Flamm S, Inadomi J, Ko C, Muniraj T, O’Shea R, Pandolfino J, Patel A, Sharaf R, Siddique S, Su G, Wang K, Weizman A. AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis. Gastroenterology 2018, 156: 748-764. PMID: 30576644, PMCID: PMC6858922, DOI: 10.1053/j.gastro.2018.12.009.Peer-Reviewed Original ResearchCannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Pancreas 2018, 47: 1142-1149. PMID: 30134357, DOI: 10.1097/mpa.0000000000001143.Peer-Reviewed Original ResearchConceptsPost-endoscopic retrograde cholangiopancreatography pancreatitisIncidence risk ratioCholangiopancreatography pancreatitisCannabis useRisk of PEPEndoscopic retrograde cholangiopancreatography pancreatitisUS Nationwide Inpatient SampleRate of PEPShorter hospital stayNationwide Inpatient SampleNinth Edition codesImpact of cannabisPoisson regression modelsHospital deathHospital stayIndependent predictorsEdition codesRisk ratioInpatient SampleInternational ClassificationMultivariate analysisPancreatitisPatientsCannabisSignificant increase
2017
Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States
Bellin MD, Whitcomb DC, Abberbock J, Sherman S, Sandhu BS, Gardner TB, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Cote GA, Guda NM, Muniraj T, Tang G, Brand RE, Gelrud A, Amann ST, Forsmark CE, Wilcox CM, Slivka A, Yadav D. Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States. The American Journal Of Gastroenterology 2017, 112: 1457. PMID: 28741615, PMCID: PMC6168293, DOI: 10.1038/ajg.2017.181.Peer-Reviewed Original ResearchConceptsDiabetes mellitusChronic pancreatitisRisk factorsPancreas surgeryFamily historyType 2 diabetes mellitusMultivariate logistic regression modelingDM risk factorsLarge multicenter cohortStrong risk factorCross-sectional assessmentLogistic regression modelingCommon complicationCP patientsPatient demographicsMulticenter cohortExocrine insufficiencyPancreatic calcificationSingle centerDisease characteristicsDM diagnosisMultivariable modelSingle etiologyHigher oddsPatientsValidation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group
Conwell DL, Banks PA, Sandhu BS, Sherman S, Al-Kaade S, Gardner TB, Anderson MA, Wilcox CM, Lewis MD, Muniraj T, Forsmark CE, Cote GA, Guda NM, Tian Y, Romagnuolo J, Wisniewski SR, Brand R, Gelrud A, Slivka A, Whitcomb DC, Yadav D. Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. Digestive Diseases And Sciences 2017, 62: 2133-2140. PMID: 28600657, PMCID: PMC6040886, DOI: 10.1007/s10620-017-4621-z.Peer-Reviewed Original ResearchConceptsRisk factorsIdiopathic etiologyEpidemiologic trendsChronic pancreatitis patientsRecent epidemiologic trendsMultiple risk factorsCurrent epidemiologic trendsNAPS2 studyAlcohol etiologyCP patientsYounger patientsChronic pancreatitisCommon etiologyPancreatitis patientsMean ageConclusionOur dataUS CentersStudy groupEtiologyObjectivesOur aimPatientsGenetic etiologySmokingDemographic factorsValidation study
2016
Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women
Romagnuolo J, Talluri J, Kennard E, Sandhu BS, Sherman S, Cote GA, Al-Kaade S, Gardner TB, Gelrud A, Lewis MD, Forsmark CE, Guda NM, Conwell DL, Banks PA, Muniraj T, Wisniewski SR, Tian Y, Wilcox CM, Anderson MA, Brand RE, Slivka A, Whitcomb DC, Yadav D. Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women. Pancreas 2016, 45: 934-940. PMID: 26967451, PMCID: PMC4940220, DOI: 10.1097/mpa.0000000000000616.Peer-Reviewed Original ResearchConceptsChronic pancreatitisNonalcoholic etiologyMulticenter US cohortEndocrine insufficiencyAlcohol etiologyClinical profileMedical therapyNorth American womenUS cohortRisk factorsChronic diseasesMorphologic findingsAlcoholic malesPain experienceCP casesClinical phenotypeEtiologyDetailed questionnaireWomenDiseaseAmerican womenPancreatitisPatientsRecent dataDemographics
2014
Chronic Pancreatitis Pain Pattern and Severity Are Independent of Abdominal Imaging Findings
Wilcox CM, Yadav D, Ye T, Gardner TB, Gelrud A, Sandhu BS, Lewis MD, Al-Kaade S, Cote GA, Forsmark CE, Guda NM, Conwell DL, Banks PA, Muniraj T, Romagnuolo J, Brand RE, Slivka A, Sherman S, Wisniewski SR, Whitcomb DC, Anderson MA. Chronic Pancreatitis Pain Pattern and Severity Are Independent of Abdominal Imaging Findings. Clinical Gastroenterology And Hepatology 2014, 13: 552-560. PMID: 25424572, PMCID: PMC5019545, DOI: 10.1016/j.cgh.2014.10.015.Peer-Reviewed Original ResearchConceptsPain patternsChronic pancreatitisImaging findingsAbdominal painAbdominal imagingCross-sectional abdominal imagingAbdominal imaging featuresPancreatic ductal dilatationCommon imaging findingsSeverity of painAbdominal imaging findingsEvaluation of patientsPattern of painProspective multicenter studyAbdominal imaging techniquesEndoscopic retrograde cholangiopancreatographyCase report formsClinical research coordinatorsMild painDuctal dilatationPain severitySevere painPatient's painDuctal changesMulticenter study