2022
Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression
Fu D, Blobner B, Greer P, Lafyatis R, Bellin M, Whitcomb D, Study P, Bellin M, Beilman G, Study G, Brand R, Ohlsen C, Saloman J, Whitcomb D, Park H, Lee K, Paniccia A, Zureikat A, Group N, Alkaade S, Amann S, Anderson M, Banks P, Conwell D, Cote G, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Papachristou G, Romagnuolo J, Sandhu B, Sherman S, Singh V, Slivka A, Wilcox C, Yadav D. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression. Gastroenterology 2022, 164: 289-292.e4. PMID: 36191639, PMCID: PMC9892203, DOI: 10.1053/j.gastro.2022.09.036.Peer-Reviewed Original ResearchMeSH KeywordsGenetic Predisposition to DiseaseHaplotypesHumansMutationPancreatitis, ChronicReceptors, Antigen, T-CellTrypsinTrypsinogen
2021
Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain
Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC, Consortium F. Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain. The American Journal Of Gastroenterology 2021, 116: 2128-2136. PMID: 34236339, PMCID: PMC8531869, DOI: 10.14309/ajg.0000000000001366.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnxiety DisordersCohort StudiesFemaleGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseHumansMaleMiddle AgedPainPancreatitis, ChronicStress Disorders, Post-TraumaticWhite PeopleConceptsPost-traumatic stress disorderChronic pancreatitisSevere painPain experienceThird of patientsPain management strategiesIdentification of patientsAbsence of painInflammatory syndromePain patternsCP patientsPain categoriesPain locusStudy cohortAcute pancreatitisAdrenal axisCP subjectsPainGenetic predispositionPatientsPsychiatric conditionsGenetic risk lociPTSD riskPancreatitisStress disorder
2019
Chronic Pancreatitis
Schwarzenberg SJ, Uc A, Zimmerman B, Wilschanski M, Wilcox CM, Whitcomb DC, Werlin SL, Troendle D, Tang G, Slivka A, Singh VK, Sherman S, Shah U, Sandhu BS, Romagnuolo J, Rhee S, Pohl JF, Perito ER, Ooi CY, Nathan JD, Muniraj T, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Lewis M, Husain SZ, Himes R, Heyman MB, Guda N, Gonska T, Giefer MJ, Gelrud A, Gariepy CE, Gardner TB, Freedman SD, Forsmark CE, Fishman DS, Cote GA, Conwell D, Brand RE, Bellin M, Barth B, Banks PA, Anderson MA, Amann ST, Alkaade S, Abu‐El‐Haija M, Abberbock JN, Lowe ME, Yadav D. Chronic Pancreatitis. Journal Of Pediatric Gastroenterology And Nutrition 2019, 68: 566-573. PMID: 30897605, PMCID: PMC6492264, DOI: 10.1097/mpg.0000000000002279.Peer-Reviewed Original ResearchConceptsChronic pancreatitisRisk factorsGenetic risk factorsOnly risk factorEmergency room visitsInternational Study GroupAge of onsetWork/schoolDisease durationPediatric pancreatitisRoom visitsDiabetes prevalenceRadiographic findingsAppropriate statistical testsPancreatic insufficiencyChildhood onsetStudy groupSecondary analysisCohortNatural historyPancreatitisCP treatmentAdultsChildrenLength of time
2014
Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features
Muniraj T, Aslanian HR, Farrell J, Jamidar PA. Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features. Disease-a-Month 2014, 60: 530-550. PMID: 25510320, DOI: 10.1016/j.disamonth.2014.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingCausalityComorbidityDyslipidemiasGallbladder DiseasesGenetic Predisposition to DiseaseGlobal HealthHepatitis, Viral, HumanHumansPancreatitis, ChronicPrevalenceRisk FactorsSeverity of Illness Index
2012
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann S, Anderson M, Baillie J, Banks P, Conwell D, Coté G, Cotton P, DiSario J, Farrer L, Forsmark C, Johnstone M, Gardner T, Gelrud A, Greenhalf W, Haines J, Hartman D, Hawes R, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem N, Money M, Muniraj T, Papachristou G, Pericak-Vance M, Romagnuolo J, Schellenberg G, Sherman S, Simon P, Singh V, Slivka A, Stolz D, Sutton R, Weiss F, Wilcox C, Zarnescu N, Wisniewski S, O'Connell M, Kienholz M, Roeder K, Barmada M, Yadav D, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature Genetics 2012, 44: 1349-1354. PMID: 23143602, PMCID: PMC3510344, DOI: 10.1038/ng.2466.Peer-Reviewed Original ResearchMeSH KeywordsClaudinsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHomozygoteHumansMaleMutationPancreatitis, AlcoholicSex FactorsTrypsinTrypsinogen