2020
Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort
Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, LaRusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, Singh VK, Yadav D, Whitcomb DC. Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort. Journal Of Gastroenterology 2020, 55: 1000-1009. PMID: 32681239, PMCID: PMC9124361, DOI: 10.1007/s00535-020-01703-w.Peer-Reviewed Original ResearchConceptsConstant severe painRecurrent acute pancreatitisChronic pancreatitisDepression-associated genesCP patientsPain severityAntidepressant usePancreatitis patientsPain experienceProspective randomized trialsAntidepressant medication usePattern of painCase report formsChronic opioidsIslet autotransplantationAntidepressant therapyTotal pancreatectomyMedication usePain managementRandomized trialsCounseling patientsRetrospective studyAcute pancreatitisClinical trialsMajor depression
2019
Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus
Goodarzi MO, Nagpal T, Greer P, Cui J, Chen YI, Guo X, Pankow JS, Rotter JI, Alkaade S, Amann ST, Baillie J, Banks PA, Brand RE, Conwell DL, Cote GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, LaRusch J, Lewis MD, Money ME, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Singh VK, Wilcox CM, Pandol SJ, Park WG, Andersen DK, Bellin MD, Hart PA, Yadav D, Whitcomb DC. Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus. Clinical And Translational Gastroenterology 2019, 10: e00057. PMID: 31232720, PMCID: PMC6708663, DOI: 10.14309/ctg.0000000000000057.Peer-Reviewed Original ResearchConceptsGenetic risk scoreDiabetes mellitusChronic pancreatitisCP-DMPancreatogenic diabetesRisk scoreNorth American Pancreatitis Study 2Type 2 diabetes mellitusLarge prospective studiesSingle nucleotide polymorphismsMulti-Ethnic StudyWeighted genetic risk scoreMean genetic risk scoreDiabetic groupNondiabetic controlsProspective studyNucleotide polymorphismsPathophysiologic entityFamily historyT2DMDiabetesType 2Separate disordersGold standardMellitus
2016
Pharmacologic Therapies in Gastrointestinal Diseases
Fox RK, Muniraj T. Pharmacologic Therapies in Gastrointestinal Diseases. Medical Clinics Of North America 2016, 100: 827-850. PMID: 27235617, DOI: 10.1016/j.mcna.2016.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAntacidsAnti-Bacterial AgentsAntidepressive AgentsAntidiarrhealsAntiviral AgentsCoinfectionDietary FiberDrug Resistance, ViralGastroesophageal RefluxGastrointestinal AgentsGastrointestinal DiseasesGenotypeHelicobacter InfectionsHepatitis CHistamine H2 AntagonistsHIV InfectionsHumansIrritable Bowel SyndromeLaxativesPeptic UlcerProbioticsProton Pump InhibitorsConceptsGastroesophageal reflux diseaseIrritable bowel syndromeProton pump inhibitorsHepatitis C virusBowel syndromeFirst-line treatmentMainstay of therapyPeptic ulcer diseaseLong-term useHCV treatmentReflux diseaseMost patientsPharmacologic therapyDuodenal ulcerUlcer diseasePump inhibitorsC virusGastrointestinal diseasesTreatment candidatesPermanent cureSevere symptomsSide effectsDiseaseHigher likelihoodPharmacotherapy