2016
Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity
Hayman T, Contessa J. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity. Cancer Drug Discovery And Development 2016, 35-55. DOI: 10.1007/978-3-319-40854-5_2.Peer-Reviewed Original ResearchReceptor tyrosine kinasesTumor radiosensitivityCombination of radiotherapyTyrosine kinaseMost solid tumorsField of oncologyClinical findingsClinical prognosisMaintenance/progressionIGF-1RRadiation therapyClinical investigationAforementioned receptorsSolid tumorsC-MetModest responseTherapyRadiation oncologyOncologyCancer therapyRadiotherapyAttractive targetRadiosensitivityCellular responsesAgents
2013
The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells
Kahn J, Hayman T, Jamal M, Rath B, Kramp T, Camphausen K, Tofilon P. The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells. Neuro-Oncology 2013, 16: 29-37. PMID: 24311635, PMCID: PMC3870843, DOI: 10.1093/neuonc/not139.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBenzamidesBrain NeoplasmsCell CycleCell ProliferationDNA Breaks, Double-StrandedDNA RepairFemaleFluorescent Antibody TechniqueGlioblastomaHistonesHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MiceMice, NudeMorpholinesMultiprotein ComplexesNeoplastic Stem CellsProtein Kinase InhibitorsPyrimidinesRadiation-Sensitizing AgentsTOR Serine-Threonine KinasesTumor Cells, CulturedXenograft Model Antitumor AssaysX-Ray TherapyConceptsGBM stem-like cellsDual mTORC1/2 inhibitorStem-like cellsOrthotopic xenograftsMTORC1/2 inhibitorsPrimary treatment modalityΓH2AX fociRadiation-induced γH2AX fociGlioblastoma stem-like cellsTreatment modalitiesClonogenic survival analysisGBM therapyMTOR inhibitorsSurvival analysisGSC cell linesClonogenic assayMammalian targetVivo responseAZD2014GlioblastomaIndividual treatmentRadiosensitivityCell linesXenograftsImmunoblot analysis