2023
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cell Therapy for B-Cell Lymphomas: An ILROG Multi-Institutional Study
Yegya-Raman N, Wright C, Ladbury C, Chew J, Zhang S, Sun S, Burke S, Baron J, Sim A, LaRiviere M, Yang J, Robinson T, Tseng Y, Terezakis S, Braunstein S, Dandapani S, Schuster S, Chong E, Plastaras J, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cell Therapy for B-Cell Lymphomas: An ILROG Multi-Institutional Study. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: s50-s51. DOI: 10.1016/j.ijrobp.2023.06.333.Peer-Reviewed Original ResearchImmune effector cell-associated neurotoxicity syndromeProgression-free survivalCytokine release syndromeB-cell lymphomaChimeric antigen receptor T-cell therapySuperior progression-free survivalLarge B-cell lymphomaCAR-T infusionT-cell therapyMulti-institutional studyOverall survivalCTCAE v5.0T infusionTisa-celCAR TRefractory aggressive B-cell lymphomasStage III/IV diseaseT-cell/histiocyte-rich large B-cell lymphomaFavorable progression-free survivalCentral nervous system involvementDiffuse large B-cell lymphomaAggressive B-cell lymphomasPrimary mediastinal B-cell lymphomaMediastinal B-cell lymphomaNervous system involvementEpstein‑Barr virus‑associated primary central nervous system lymphoma in an immunosuppressed patient with a comorbid autoimmune disorder: A case report
Bricoune O, Kareem S, Wallace G, Iacono D, Macaulay R, Etame A, Pina Y, Robinson T, Mokhtari S. Epstein‑Barr virus‑associated primary central nervous system lymphoma in an immunosuppressed patient with a comorbid autoimmune disorder: A case report. Experimental And Therapeutic Medicine 2023, 26: 410. PMID: 37522053, PMCID: PMC10375448, DOI: 10.3892/etm.2023.12109.Peer-Reviewed Original ResearchPrimary central nervous system lymphomaEpstein-Barr virusCentral nervous system lymphomaDiffuse large B-cell lymphomaNervous system lymphomaMycophenolate mofetilMemory lossSystem lymphomaPeriventricular lesionsEnhancing lesionsBrain MRIEpstein-Barr virus-associated primary central nervous system lymphomaAcetylcholine receptor antibody-positive myasthenia gravisNon-focal neurological symptomsSubsequent chronic kidney diseaseVaricella zoster virus (VZV) vasculopathyAntibody-positive myasthenia gravisWhole-brain radiation therapyLarge B-cell lymphomaComorbid autoimmune disordersLeft eye visionRepeat brain MRIHigh-dose methotrexateVaricella zoster infectionChronic kidney disease
2021
NCMP-08. CHALLENGING DIAGNOSIS AND MANAGEMENT OF PCNSL IN AN IMMUNOSUPPRESSED PATIENT ON MYCOPHENOLATE MOFETIL FOR MYASTHENIA GRAVIS
Bricoune O, Mokhtari S, Etame A, Robinson T, Pina Y, Macaulay R. NCMP-08. CHALLENGING DIAGNOSIS AND MANAGEMENT OF PCNSL IN AN IMMUNOSUPPRESSED PATIENT ON MYCOPHENOLATE MOFETIL FOR MYASTHENIA GRAVIS. Neuro-Oncology 2021, 23: vi148-vi149. DOI: 10.1093/neuonc/noab196.581.Peer-Reviewed Original ResearchPrimary CNS lymphomaDiffuse large B-cell lymphomaMycophenolate mofetilMyasthenia gravisEnhancing lesionsBrain MRIAcetylcholine receptor antibody-positive myasthenia gravisDiagnosis of PCNSLManagement of PCNSLAntibody-positive myasthenia gravisLarge B-cell lymphomaLeft eye visionRepeat brain MRIFocal neurological deficitsCerebrospinal fluid analysisPositive myasthenia gravisGross total resectionPeriventricular white matterLeft frontal lesionNew enhancing lesionsAdditional diagnostic testsB-cell lymphomaLeft medullaOral prednisoneRituximab IV
2018
Radiation Therapy As a Bridging Strategy for Refractory Diffuse Large B Cell Lymphoma Patients Awaiting CAR T Manufacturing of Axicabtagene Ciloleucel
Jain M, Chavez J, Shah B, Khimani F, Lazaryan A, Davila M, Liu H, Falchook A, Robinson T, Kim S, Locke F. Radiation Therapy As a Bridging Strategy for Refractory Diffuse Large B Cell Lymphoma Patients Awaiting CAR T Manufacturing of Axicabtagene Ciloleucel. Blood 2018, 132: 4220. DOI: 10.1182/blood-2018-99-117133.Peer-Reviewed Original ResearchCytokine release syndromeAxi-cel therapyCAR-T infusionCy conditioningCase seriesT infusionTumor burdenAxicabtagene ciloleucelCAR TSpeakers bureauRadiation therapyRefractory diffuse large B-cell lymphoma patientsRefractory diffuse large B-cell lymphomaChimeric antigen receptor T-cell therapyPatient experienced progressive diseaseSevere cytokine release syndromeDiffuse large B-cell lymphoma patientsDisease controlLarge B-cell lymphoma patientsB-cell lymphoma patientsDiffuse large B-cell lymphomaAdvisory CommitteeLarge B-cell lymphomaCAR T cell efficacyExperienced progressive disease