Trends and Challenges in Experimental Macromolecular Crystallography
Chayen N, Boggon T, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop S, Helliwell J, Nieh Y, Peterson M, Raftery J, Snell E, Hädener A, Niemann A, Siddons D, Stojanoff V, Thompson A, Ursby T, Wulff M. Trends and Challenges in Experimental Macromolecular Crystallography. Quarterly Reviews Of Biophysics 1996, 29: 227-278. PMID: 8968112, DOI: 10.1017/s0033583500005837.Peer-Reviewed Original ResearchConceptsHuman genome sequencing projectGenome sequencing projectsModern drug discoveryStructural molecular biologyPrimary sequencingYeast genomeBiological chemistryStructural chemistrySequencing projectsBiological macromoleculesStructural DatabaseRational designMolecular biologyCognate ligandsDrug discoveryMolecular interactionsEnzyme reactivityMacromolecular crystallographyNovel inhibitorsChemistryNucleic acidsVirus structureFunctional detailsStructural detailsPharmaceutical industry