2013
The value of mutational profiling of the cytocentrifugation supernatant fluid from fine-needle aspiration of pancreatic solid mass lesions
Deftereos G, Finkelstein S, Jackson S, Ellsworth E, Krishnamurti U, Liu Y, Silverman J, Binkert C, Ujevich B, Mohanty A. The value of mutational profiling of the cytocentrifugation supernatant fluid from fine-needle aspiration of pancreatic solid mass lesions. Modern Pathology 2013, 27: 594-601. PMID: 24051700, DOI: 10.1038/modpathol.2013.147.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBiomarkers, TumorBiopsy, Fine-NeedleCentrifugationDNA Mutational AnalysisDNA, NeoplasmGenetic Predisposition to DiseaseHumansLoss of HeterozygosityMicrodissectionMutationPancreatic NeoplasmsPolymerase Chain ReactionPredictive Value of TestsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsConceptsFine-needle aspirationPancreatic solid massesDiagnostic yieldSupernatant fluidTumor DNASolid massHigh clinical suspicionDetectable mutationsSolid mass lesionQuantitative PCRClinical suspicionAtypical cellsDefinitive diagnosisMass lesionCytology smearsFluid specimensFNA smearsMolecular analysisAdjunct methodAdequate DNAMutational profilingCell blocksCytocentrifugation supernatant fluidSmearsBroad panel
2007
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Krishnamurti U, Sasatomi E, Swalsky P, Finkelstein S, Ohori N. Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations? Archives Of Pathology & Laboratory Medicine 2007, 131: 74-80. PMID: 17227126, DOI: 10.5858/2007-131-74-aolohi.Peer-Reviewed Original ResearchConceptsK-ras mutationsBile duct brushingsLoss of heterozygosityMalignant outcomeFractional allelic lossDuct brushingsCytology casesAllelic lossMolecular alterationsBile duct brushing cytologyPilot studyConventional cytologic evaluationSurgical pathology specimenCorresponding surgical specimensDuct brushing cytologySurgical pathology specimensDetection of malignancySubtle molecular alterationsSurgical outcomesSurgical specimenPathology specimenCytologic findingsSurgical specimensBrushing cytologyCytologic evaluation