2023
Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice
Kam C, Singh I, Gonzalez D, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi K, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell 2023, 186: 2345-2360.e16. PMID: 37167971, PMCID: PMC10225355, DOI: 10.1016/j.cell.2023.04.017.Peer-Reviewed Original ResearchConceptsAdult endothelial cellsNeonatal endothelial cellsEndothelial cellsVascular maturationAdult homeostasisOrgan growthAdult maintenanceHomeostasisLive miceVessel regressionFundamental mechanismsGlobal ablationLocal ablationMaturationNetwork perfusionVascular plexusBlood vesselsLongitudinal imagingVessel repairMaintenanceVascular architecturePlexusFunctional networksMiceMechanism
2018
Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo
Marsh E, Gonzalez DG, Lathrop EA, Boucher J, Greco V. Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo. Cell 2018, 175: 1620-1633.e13. PMID: 30415836, PMCID: PMC7605015, DOI: 10.1016/j.cell.2018.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCell NucleusCells, CulturedFibroblastsHomeostasisMiceMice, TransgenicSkinConceptsCore cellular mechanismsFibroblast homeostasisRac1-dependent mannerNeighboring fibroblastsMembrane occupancyMembrane extensionsNucleus organizationCellular mechanismsHomeostasisFibroblast membranesAbsence of migrationFibroblastsCell occupancySkin fibroblastsProgressive accumulationVivoStructural componentsLifespan of miceLive miceOccupancyMicePositional stabilityMembraneLifespanAccumulation