2018
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.Peer-Reviewed Original ResearchConceptsMouse mammary glandMilk-producing epithelial cellsTissue-specific rolesMammary glandAdipose growthLipid dynamicsGenetic tracingPhysiological examplesFunctional implicationsCellular mechanismsAdipocyte hypertrophyMature adipocytesEssential roleVivo analysisTissue functionMammary epitheliumAdipocytesEpithelial cellsAdipocyte precursorsSubsequent involutionMilk lipidsPrimary mechanismMechanismLipidomicsMilk fat production
2009
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
Horsley V. Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection. Journal Of Cell Biology 2009, 185: 761-763. PMID: 19487452, PMCID: PMC2711585, DOI: 10.1083/jcb.200904125.Peer-Reviewed Original Research
2007
Reprogramming somatic cells to their embryonic state
Horsley V, Fuchs E. Reprogramming somatic cells to their embryonic state. All Life 2007, 1: 89-93. PMID: 19404413, PMCID: PMC2639841, DOI: 10.2976/1.2757614.Peer-Reviewed Original ResearchES cellsSomatic cellsPluripotent fateStem cellsEmbryonic stem cellsES-like cellsHuman ES cellsCell Stem CellTranscription factorsEmbryonic cellsAdult bodyPluripotent potentialHuman diseasesTypes of cellsEmbryonic stateAbility of scientistsRegenerative medicineEmbryosCellsRegenerative therapyFatePluripotencyLineagesMechanismExpression