2007
Epithelial Stem Cells: Turning over New Leaves
Blanpain C, Horsley V, Fuchs E. Epithelial Stem Cells: Turning over New Leaves. Cell 2007, 128: 445-458. PMID: 17289566, PMCID: PMC2408375, DOI: 10.1016/j.cell.2007.01.014.Peer-Reviewed Original ResearchConceptsEpithelial stem cell maintenanceStem cell maintenanceEpithelial stem cell biologyStem cell biologyStem cellsUnipotent progenitor cellsCommon signaling pathwaysEpithelial-mesenchymal interactionsMultipotent stem cellsMost epithelial tissuesLineage determinationCell maintenanceCell biologyNew leavesEpithelial stem cellsSignaling pathwaysHuman disordersHuman diseasesFunctional differencesProgenitor cellsEpithelial tissuesRegenerative medicineMajor clinical implicationsPathwayCells
2006
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland. Cell 2006, 126: 597-609. PMID: 16901790, PMCID: PMC2424190, DOI: 10.1016/j.cell.2006.06.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBromodeoxyuridineCell CountCell DifferentiationCell LineageCell MovementCell ProliferationCells, CulturedEpithelial CellsGene Expression Regulation, DevelopmentalHair FollicleHyperplasiaMiceMice, KnockoutMice, TransgenicMultipotent Stem CellsPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-mycRepressor ProteinsSebaceous GlandsStem CellsTranscription FactorsConceptsMultipotent stem cellsCellular inputsGenetic lineage tracingStem cellsUnipotent progenitor cellsTranscriptional repressor Blimp1Stem cell activityElevated c-myc expressionLineage commitmentC-myc expressionBrdU-labeling experimentsLineage tracingProgenitor populationsLineagesBlimp1Progenitor cellsCell proliferationLabeling experimentsSebaceous glandsCellsCell culture studiesSG homeostasisHair folliclesHomeostasisGland