2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAnimalsCD24 AntigenCell ProliferationCell Self RenewalDermisGene Expression ProfilingHyperplasiaMice, Inbred C57BLModels, BiologicalPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaSignal TransductionSkinStem CellsConceptsAdipocyte stem cellsAdipogenic programLipid-filled mature adipocytesStem Cell Self-RenewalCell Self-RenewalDistinct regulatory mechanismsASC proliferationPI3K/Akt2Stem cell populationWhite adipose tissueUnrecognized regulatorSelf-RenewalRegulatory mechanismsGenetic studiesMature adipocytesPDGFA expressionStem cellsCell populationsTissue growthProliferationActive mechanismDifferent WAT depotsHair growthMaintenanceAkt2
2014
Chapter Four Epithelial Stem Cells in Adult Skin
Tadeu AM, Horsley V. Chapter Four Epithelial Stem Cells in Adult Skin. Current Topics In Developmental Biology 2014, 107: 109-131. PMID: 24439804, PMCID: PMC5595246, DOI: 10.1016/b978-0-12-416022-4.00004-4.Peer-Reviewed Original ResearchConceptsAdult skin epitheliumTissue-specific stem cellsDifferent stem cell populationsStem cellsStem cell nicheNormal skin homeostasisStem cell populationStem cell activityCell nicheEpithelial stem cellsSkin homeostasisAbnormal regulationCell populationsAdult skinSkin epitheliumExtrinsic componentsEnvironmental aggressionsCellsNicheAdult lifeHomeostasisFirst lineRegulationRecent effortsCell activity
2008
More than one way to skin . . .
Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.Peer-Reviewed Original ResearchConceptsStem cellsMultiple signaling networksNormal tissue homeostasisStem cell nicheStem cell populationResident stem cellsEpithelial-mesenchymal interactionsCell populationsCell fateSignaling networksSpecific lineagesTissue homeostasisCell nicheEpithelial stem cellsEpithelial lineageRecent cluesNormal homeostasisEpithelial tissuesLineagesWound repairHomeostasisCellsHair folliclesNicheFate