2021
Fibroblasts: Origins, definitions, and functions in health and disease
Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, Driskell RR, Rosenthal N, Biernaskie J, Horsley V. Fibroblasts: Origins, definitions, and functions in health and disease. Cell 2021, 184: 3852-3872. PMID: 34297930, PMCID: PMC8566693, DOI: 10.1016/j.cell.2021.06.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineageDiseaseFibroblastsHealthHumansMolecular Targeted TherapySignal TransductionConceptsDiverse mesenchymal cellsComplex extracellular matrixCell fateCellular progenyTissue homeostasisCell cycleBiochemical cuesReversible plasticityExtracellular matrixPositional informationMesenchymal cellsSkeletal muscleTissue repairFibrotic disordersFibroblastsLineagesNicheProgenyHomeostasisPhenotypeOrgansFatePlasticityCellsFunction
2020
Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle–Dependent Dermal Adipose Expansion
Rivera-Gonzalez GC, Klopot A, Sabin K, Baida G, Horsley V, Budunova I. Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle–Dependent Dermal Adipose Expansion. Journal Of Investigative Dermatology 2020, 140: 1698-1705.e1. PMID: 32032578, PMCID: PMC7398827, DOI: 10.1016/j.jid.2019.12.033.Peer-Reviewed Original ResearchConceptsWhite adipose tissueAdipocyte precursor cellsAdipose tissueProtein kinase B signalingDNA damage response 1Loss of REDD1Precursor cellsProtein kinase BAdipogenic marker expressionKinase B signalingHigher lipid accumulationInguinal subcutaneous white adipose tissueGonadal white adipose tissueInterscapular brown adipose tissueSubcutaneous white adipose tissueWhite adipose tissue expansionNegative regulatorPostnatal day 18Wild-type miceAdipose tissue expansionKinase BRegulated developmentBrown adipose tissueHair growth cycleResponse 1
2017
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM. E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning. Nature Communications 2017, 8: 1250. PMID: 29093447, PMCID: PMC5665913, DOI: 10.1038/s41467-017-01170-7.Peer-Reviewed Original ResearchTregs Expand the Skin Stem Cell Niche
Horsley V, Naik S. Tregs Expand the Skin Stem Cell Niche. Developmental Cell 2017, 41: 455-456. PMID: 28586641, DOI: 10.1016/j.devcel.2017.05.020.Peer-Reviewed Original Research
2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAnimalsCD24 AntigenCell ProliferationCell Self RenewalDermisGene Expression ProfilingHyperplasiaMice, Inbred C57BLModels, BiologicalPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaSignal TransductionSkinStem CellsConceptsAdipocyte stem cellsAdipogenic programLipid-filled mature adipocytesStem Cell Self-RenewalCell Self-RenewalDistinct regulatory mechanismsASC proliferationPI3K/Akt2Stem cell populationWhite adipose tissueUnrecognized regulatorSelf-RenewalRegulatory mechanismsGenetic studiesMature adipocytesPDGFA expressionStem cellsCell populationsTissue growthProliferationActive mechanismDifferent WAT depotsHair growthMaintenanceAkt2Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade
Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C. Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. The FASEB Journal 2016, 30: 2837-2848. PMID: 27127101, PMCID: PMC4970601, DOI: 10.1096/fj.201500027r.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorOsteogenesis imperfecta type VIWnt/β-catenin signalingBone massOI type VIΒ-catenin signalingAbility of PEDFTrabecular bone volume/total volumeType VIBone volume/total volumeWild-type miceEpithelium-derived factorBone plasticityPEDF-knockout miceMesenchymal stem cell commitmentBone volume fractionKO micePEDF peptidesStem cell commitmentFluorescent protein reporterCombination of Wnt3aMouse modelWnt modulatorsBone mineralizationMice
2014
Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation
Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes & Development 2014, 28: 983-994. PMID: 24732379, PMCID: PMC4018496, DOI: 10.1101/gad.236554.113.Peer-Reviewed Original ResearchConceptsStem cell quiescenceStem cell nicheHair follicle (HF) SCsTranscription factor nuclear factorJAK/STAT5Hormonal signalingMolecular circuitryActivated T cells c1Phosphatase calcineurinCell nicheSC quiescenceCell quiescenceT cells c1Calcineurin/NFATc1Function experimentsGenetic changesCanonical activationPharmacological lossPRL injectionsSC activationProlactin receptorMost tissuesTissue environmentHF SCsNuclear factor
2013
Notch signaling represses p63 expression in the developing surface ectoderm
Tadeu AM, Horsley V. Notch signaling represses p63 expression in the developing surface ectoderm. Development 2013, 140: 3777-3786. PMID: 23924630, PMCID: PMC3754476, DOI: 10.1242/dev.093948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationEctodermEmbryonic Stem CellsEpidermal CellsEpidermisGene Expression Regulation, DevelopmentalHumansKeratin-14KeratinocytesMiceModels, BiologicalPhosphoproteinsReceptors, NotchRepressor ProteinsSignal TransductionStem CellsTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsConceptsHuman embryonic stem cellsProgenitor cellsMouse embryosKeratinocyte lineageProgenitor cell specificationEmbryonic stem cellsNegative regulatory roleKeratinocyte fateCell specificationEctodermal specificationInhibition of NotchTranscriptional changesMolecular controlNotch signalingRegulatory roleSurface ectodermP63 expressionStem cellsCoordinated sequenceLineagesMature epidermisEmbryosKeratin 14ExpressionCells
2012
IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin
McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin. Journal Of Investigative Dermatology 2012, 133: 1321-1329. PMID: 23223145, PMCID: PMC3610794, DOI: 10.1038/jid.2012.463.Peer-Reviewed Original ResearchConceptsIL-22Immune cellsCytokine IL-22Epithelial cellsWound repairIL-22 signalingDermal compartmentFull-thickness woundingAcute injuryPeripheral tissuesSkin wound repairEpithelial regenerationMyofibroblast differentiationSkin woundingEpidermal barrierExtracellular matrix gene expressionMatrix gene expressionInjuryVivo roleSkin repairMiceUnidentified roleFibroblastsRepairUnidirectional signalingDevelopment and homeostasis of the sebaceous gland
Niemann C, Horsley V. Development and homeostasis of the sebaceous gland. Seminars In Cell And Developmental Biology 2012, 23: 928-936. PMID: 22960253, PMCID: PMC5595243, DOI: 10.1016/j.semcdb.2012.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHomeostasisHumansSebaceous GlandsSignal TransductionSkin DiseasesTranscription, GeneticConceptsDistinct signaling pathwaysSebaceous gland biologyLipid composition resultsLineage differentiationSignaling pathwaysGland developmentNormal developmentSkin homeostasisMammalian skinEpidermal appendagesTumor formationCell linesCurrent knowledgeDifferentiationCrucial mediatorLipid metabolismAtrophic sebaceous glandsNew insightsVivo mechanismsHomeostasisSebaceous glandsAbnormal proliferationSebaceous gland developmentProliferationImportant roleHome sweet home: skin stem cell niches
Goldstein J, Horsley V. Home sweet home: skin stem cell niches. Cellular And Molecular Life Sciences 2012, 69: 2573-2582. PMID: 22410738, PMCID: PMC3449145, DOI: 10.1007/s00018-012-0943-3.Peer-Reviewed Original Research
2009
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
Horsley V. Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection. Journal Of Cell Biology 2009, 185: 761-763. PMID: 19487452, PMCID: PMC2711585, DOI: 10.1083/jcb.200904125.Peer-Reviewed Original Research
2007
Epithelial Stem Cells: Turning over New Leaves
Blanpain C, Horsley V, Fuchs E. Epithelial Stem Cells: Turning over New Leaves. Cell 2007, 128: 445-458. PMID: 17289566, PMCID: PMC2408375, DOI: 10.1016/j.cell.2007.01.014.Peer-Reviewed Original ResearchConceptsEpithelial stem cell maintenanceStem cell maintenanceEpithelial stem cell biologyStem cell biologyStem cellsUnipotent progenitor cellsCommon signaling pathwaysEpithelial-mesenchymal interactionsMultipotent stem cellsMost epithelial tissuesLineage determinationCell maintenanceCell biologyNew leavesEpithelial stem cellsSignaling pathwaysHuman disordersHuman diseasesFunctional differencesProgenitor cellsEpithelial tissuesRegenerative medicineMajor clinical implicationsPathwayCells