2018
Anatomical, Physiological, and Functional Diversity of Adipose Tissue
Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metabolism 2018, 27: 68-83. PMID: 29320711, PMCID: PMC6050204, DOI: 10.1016/j.cmet.2017.12.002.Peer-Reviewed Original ResearchConceptsStem cell quiescenceInnate immune barrierNon-traditional functionsFunctional diversityEpithelial stem cell quiescenceMammary glandCell quiescenceOrgan regenerationAdipocyte progenitorsHair folliclesNeighboring cellsMetabolic functionsRange of cancersNovel therapeutic approachesAdipose tissue depotsBacterial invasionAdipocytesProgenitorsAutoimmune disordersImmune barrierTherapeutic approachesClose associationAdipose tissueBone marrowTissue depots
2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAnimalsCD24 AntigenCell ProliferationCell Self RenewalDermisGene Expression ProfilingHyperplasiaMice, Inbred C57BLModels, BiologicalPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaSignal TransductionSkinStem CellsConceptsAdipocyte stem cellsAdipogenic programLipid-filled mature adipocytesStem Cell Self-RenewalCell Self-RenewalDistinct regulatory mechanismsASC proliferationPI3K/Akt2Stem cell populationWhite adipose tissueUnrecognized regulatorSelf-RenewalRegulatory mechanismsGenetic studiesMature adipocytesPDGFA expressionStem cellsCell populationsTissue growthProliferationActive mechanismDifferent WAT depotsHair growthMaintenanceAkt2The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches
Shook B, Rivera Gonzalez G, Ebmeier S, Grisotti G, Zwick R, Horsley V. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches. Annual Review Of Cell And Developmental Biology 2016, 32: 1-23. PMID: 27146311, PMCID: PMC5157158, DOI: 10.1146/annurev-cellbio-111315-125426.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsDiseaseHumansModels, BiologicalOrganogenesisRegenerationStem Cell NicheConceptsStem cell nicheFunction of WATWhite adipose tissueTissue homeostasisCell nicheMetabolic regulationNovel roleMetabolic physiologyMajor regulatorMature adipocytesImmune tissuesVivo regulationEssential roleRole of adipocytesHomeostasisWhite adipocytesAdipocytesTissue regenerationRegulationEndocrine homeostasisRegenerationTissueNicheRegulatorRole
2014
Developing stratified epithelia: lessons from the epidermis and thymus
Roberts N, Horsley V. Developing stratified epithelia: lessons from the epidermis and thymus. WIREs Mechanisms Of Disease 2014, 3: 389-402. PMID: 25176390, PMCID: PMC4283209, DOI: 10.1002/wdev.146.Peer-Reviewed Original ResearchConceptsSelf-restricted T cellsSkin epidermisNumber of organsSquamous epithelial cellsThymic epitheliumT cellsForeign pathogensMulti-layered epitheliumHair folliclesProgenitor cellsEpithelial cellsThymusEpithelial differentiation programEpitheliumStratified epitheliumEpithelial tissuesMolecular mechanismsEpidermisDifferentiation programTissueCellsNegative selectionEmbryonic germ layersChapter Four Epithelial Stem Cells in Adult Skin
Tadeu AM, Horsley V. Chapter Four Epithelial Stem Cells in Adult Skin. Current Topics In Developmental Biology 2014, 107: 109-131. PMID: 24439804, PMCID: PMC5595246, DOI: 10.1016/b978-0-12-416022-4.00004-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Basal CellCellular MicroenvironmentEpithelial CellsExocrine GlandsHumansModels, BiologicalSkinStem CellsConceptsAdult skin epitheliumTissue-specific stem cellsDifferent stem cell populationsStem cellsStem cell nicheNormal skin homeostasisStem cell populationStem cell activityCell nicheEpithelial stem cellsSkin homeostasisAbnormal regulationCell populationsAdult skinSkin epitheliumExtrinsic componentsEnvironmental aggressionsCellsNicheAdult lifeHomeostasisFirst lineRegulationRecent effortsCell activity
2013
Notch signaling represses p63 expression in the developing surface ectoderm
Tadeu AM, Horsley V. Notch signaling represses p63 expression in the developing surface ectoderm. Development 2013, 140: 3777-3786. PMID: 23924630, PMCID: PMC3754476, DOI: 10.1242/dev.093948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationEctodermEmbryonic Stem CellsEpidermal CellsEpidermisGene Expression Regulation, DevelopmentalHumansKeratin-14KeratinocytesMiceModels, BiologicalPhosphoproteinsReceptors, NotchRepressor ProteinsSignal TransductionStem CellsTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsConceptsHuman embryonic stem cellsProgenitor cellsMouse embryosKeratinocyte lineageProgenitor cell specificationEmbryonic stem cellsNegative regulatory roleKeratinocyte fateCell specificationEctodermal specificationInhibition of NotchTranscriptional changesMolecular controlNotch signalingRegulatory roleSurface ectodermP63 expressionStem cellsCoordinated sequenceLineagesMature epidermisEmbryosKeratin 14ExpressionCells
2012
Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces
Mertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V. Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 110: 842-847. PMID: 23277553, PMCID: PMC3549115, DOI: 10.1073/pnas.1217279110.Peer-Reviewed Original ResearchConceptsCell-cell adhesionExtracellular matrixIntercellular adhesionCell-matrix adhesionImportance of cadherinPrimary mouse keratinocytesTraction forceMechanical regulationFunction of tissuesCadherinColony peripheryCadherin expressionMinimal physical modelCross talkEssential roleMouse keratinocytesEpithelial tissuesEpithelial cellsContractile cellsPhysical cohesionSpatial rearrangementCellsColoniesAdhesionAdhesion typeScaling of Traction Forces with the Size of Cohesive Cell Colonies
Mertz AF, Banerjee S, Che Y, German GK, Xu Y, 徐晔, Hyland C, Marchetti M, Horsley V, Dufresne E. Scaling of Traction Forces with the Size of Cohesive Cell Colonies. Physical Review Letters 2012, 108: 198101. PMID: 23003091, PMCID: PMC4098718, DOI: 10.1103/physrevlett.108.198101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium ChlorideCell AdhesionCell CommunicationCell CountCulture MediaKeratinocytesMiceModels, BiologicalHome sweet home: skin stem cell niches
Goldstein J, Horsley V. Home sweet home: skin stem cell niches. Cellular And Molecular Life Sciences 2012, 69: 2573-2582. PMID: 22410738, PMCID: PMC3449145, DOI: 10.1007/s00018-012-0943-3.Peer-Reviewed Original Research
2011
Upward bound: follicular stem cell fate decisions
Horsley V. Upward bound: follicular stem cell fate decisions. The EMBO Journal 2011, 30: 2986-2987. PMID: 21811300, PMCID: PMC3160195, DOI: 10.1038/emboj.2011.231.Peer-Reviewed Original Research
2009
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
Horsley V. Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection. Journal Of Cell Biology 2009, 185: 761-763. PMID: 19487452, PMCID: PMC2711585, DOI: 10.1083/jcb.200904125.Peer-Reviewed Original Research
2008
More than one way to skin . . .
Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell DivisionEpidermisHair FollicleHumansModels, BiologicalSebaceous GlandsSkinStem CellsConceptsStem cellsMultiple signaling networksNormal tissue homeostasisStem cell nicheStem cell populationResident stem cellsEpithelial-mesenchymal interactionsCell populationsCell fateSignaling networksSpecific lineagesTissue homeostasisCell nicheEpithelial stem cellsEpithelial lineageRecent cluesNormal homeostasisEpithelial tissuesLineagesWound repairHomeostasisCellsHair folliclesNicheFate