2024
CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesGlutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales T, Taylor K, Alimohammadi F, Duncan R, Sechrist Z, Agostini-Vulaj D, Schafer X, Chang H, Smith Z, O’Connor T, Whelan S, Selfors L, Crowdis J, Gray G, Bronson R, Brenner D, Rufini A, Dirksen R, Hezel A, Huber A, Munger J, Cravatt B, Vasiliou V, Cole C, DeNicola G, Harris I. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature Communications 2024, 15: 6152. PMID: 39034312, PMCID: PMC11271484, DOI: 10.1038/s41467-024-50454-2.Peer-Reviewed Original ResearchConceptsGlutamate-cysteine ligase catalytic subunitLipid abundanceLipogenic enzyme expressionAbundance in vivoLipid productionCatalytic subunitRepress Nrf2Transcription factorsNrf2 repressionAdult tissuesSynthesis of GSHEnzyme expressionNon-redundantRedox bufferMouse liverLoss of GSHTriglyceride productionIn vivo modelsAbundanceGlutathione synthesisLiver balanceFat storesOxidative stressLipidDeletionA Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina D, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy J, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan Y, Chen Y, Harris I, Lang P, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation. Cell Metabolism 2024, 36: 1726-1744.e10. PMID: 38986617, DOI: 10.1016/j.cmet.2024.06.010.Peer-Reviewed Original ResearchReactive oxygen speciesMitochondrial functionCatalytic subunit of glutamate cysteine ligaseMitochondrial gene expressionDecreased cellular ATPPhosphorylation of 4E-BP1Disrupt mitochondrial functionReduced phosphorylation of 4E-BP1T cell-specific ablationCell's antioxidant mechanismsCell-specific ablationCatalytic subunitIL-22Cellular signalingIntestinal homeostasisIL-22 productionSignificant reactive oxygen speciesSubunit of glutamate cysteine ligaseGene expressionReduced IL-22 productionReduced phosphorylationCellular ATPGut protectionProtein synthesisGlutamate cysteine ligaseHepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants
Prodromou S, Chatzopoulou F, Saiti A, Giannopoulos-Dimitriou A, Koudoura L, Pantazaki A, Chatzidimitriou D, Vasiliou V, Vizirianakis I. Hepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants. Frontiers In Nutrition 2024, 11: 1388492. PMID: 38812942, PMCID: PMC11133736, DOI: 10.3389/fnut.2024.1388492.Peer-Reviewed Original ResearchNutritional supplementsLong-term effects of oxidative stressOxidative stressCell culturesReal-time PCRNatural antioxidantsEvaluate cell viabilityGene expression profilesPotential nutritional supplementEffects of oxidative stressHepG2 cell culturesMolecular pathophysiologyTherapeutic strategiesQuantitative real-time PCRInflammatory signalingAlleviate symptomsAlzheimer's diseaseLong-term effectsLong-term consequencesProliferation capacityMolecular pathwaysCell toxicityDelivery modeCellular toxicityOlive-oilLong-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study
Ma X, Fisher J, McGlynn K, Liao L, Vasiliou V, Sun N, Kaufman J, Silverman D, Jones R. Long-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study. Environment International 2024, 187: 108637. PMID: 38636274, PMCID: PMC11286199, DOI: 10.1016/j.envint.2024.108637.Peer-Reviewed Original ResearchConceptsRisk of liver cancerIncreased risk of liver cancerFine particulate matterNIH-AARP DietNIH-AARPParticulate matterHistorical PM<sub>2.5</sub> concentrationsOutdoor PM<sub>2.5</sub> levelsAmbient PM<sub>2.5</sub> levelsLong-term exposure to ambient fine particulate matterHealth StudyExposure to ambient fine particulate matterAmbient fine particulate matterAssociated with liver cancer riskYears prior to cancer diagnosisEvidence of effect modificationLiver cancer riskLiver cancer incidenceIncreased riskSpatiotemporal prediction modelAmbient PM2.5 levelsPM2.5 levelsHistorical exposure assessmentBody mass indexPhysical activityA comprehensive trial on PFAS remediation: hemp phytoextraction and PFAS degradation in harvested plants
Nason S, Thomas S, Stanley C, Silliboy R, Blumenthal M, Zhang W, Liang Y, Jones J, Zuverza-Mena N, White J, Haynes C, Vasiliou V, Timko M, Berger B. A comprehensive trial on PFAS remediation: hemp phytoextraction and PFAS degradation in harvested plants. Environmental Science Advances 2024, 3: 304-313. PMID: 38322792, PMCID: PMC10841816, DOI: 10.1039/d3va00340j.Peer-Reviewed Original ResearchPolyfluoroalkyl substancesRemoval of contaminantsPFAS-contaminated soilDegradation of polyfluoroalkyl substancesRemove PFASDegrade polyfluoroalkyl substancesExtractable organic fluorinePFAS remediationShorter-chain compoundsPFAS degradationRemediation optionsSoil samplesToxic contaminantsPFAS concentrationsPhytoremediationSoilPFAS levelsHarvested plantsHemp tissuesLonger-chainField trialsSulfonic acidContaminationRemediationOrganic fluorineEditorial overview: Unveiling 1,4-dioxane's multifaceted dimensions through a special collection
Vasiliou V. Editorial overview: Unveiling 1,4-dioxane's multifaceted dimensions through a special collection. Current Opinion In Environmental Science & Health 2024, 37: 100519. DOI: 10.1016/j.coesh.2023.100519.Peer-Reviewed Original ResearchThe European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit
Zuccaro P, Thompson D, de Boer J, Llompart M, Watterson A, Bilott R, Birnbaum L, Vasiliou V. The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit. Environmental Science And Technology 2024, 58: 2591-2594. PMID: 38301275, DOI: 10.1021/acs.est.4c00047.Peer-Reviewed Original ResearchCelebrating 20 years of human genomics: a journey of discovery
Vasiliou V. Celebrating 20 years of human genomics: a journey of discovery. Human Genomics 2024, 18: 1. PMID: 38163870, PMCID: PMC10759603, DOI: 10.1186/s40246-023-00569-2.Peer-Reviewed Original Research
2023
How Healthcare Systems Negatively Impact Environmental Health? The Need for Institutional Commitment to Reduce the Ecological Footprint of Medical Services
Piscitelli P, Karaj S, Miani A, Kyriakides T, Greco E, Colicino E, Bray A, Simón F, Vasiliou V, Baccarelli A. How Healthcare Systems Negatively Impact Environmental Health? The Need for Institutional Commitment to Reduce the Ecological Footprint of Medical Services. Epidemiologia 2023, 4: 521-524. PMID: 38131675, PMCID: PMC10871105, DOI: 10.3390/epidemiologia4040043.Peer-Reviewed Original ResearchHepatic Epigenomic Changes Associated with Chronic Oxidative Stress in a Mouse Model of Glutathione Deficiency
Chen Y, Hong S, Vasiliou V, Zhu Y. Hepatic Epigenomic Changes Associated with Chronic Oxidative Stress in a Mouse Model of Glutathione Deficiency. Free Radical Biology And Medicine 2023, 208: s13. DOI: 10.1016/j.freeradbiomed.2023.10.028.Peer-Reviewed Original ResearchAmbient fine particulate matter exposure and risk of incident liver cancer in the NIH-AARP Diet and Health Study
Ma X, Fisher J, McGlynn K, Liao L, Vasiliou V, Sun N, Kaufman J, Silverman D, Jones R. Ambient fine particulate matter exposure and risk of incident liver cancer in the NIH-AARP Diet and Health Study. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.vo-011.Peer-Reviewed Original Research
2022
Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulations
Zuccaro P, Thompson D, de Boer J, Watterson A, Wang Q, Tang S, Shi X, Llompart M, Ratola N, Vasiliou V. Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulations. Environmental Challenges 2022, 9: 100620. PMID: 36644410, PMCID: PMC9838222, DOI: 10.1016/j.envc.2022.100620.Peer-Reviewed Original ResearchEuropean UnionOnline archivesPolicy reviewNotable policiesPolicy reportsAgency officialsDirect policyGovernmental policiesMost policiesUnited NationsEnvironmental policyRespective countriesPolicyGovernmental agenciesRegulatory approachesUnited KingdomCountriesUnited StatesUnionHealth researchPublicGrey literatureEnvironmental health risksCountry regulationsSurveillance measures