2022
Germline Variant Spectrum Among African American Men Undergoing Prostate Cancer Germline Testing: Need for Equity in Genetic Testing
Giri V, Hartman R, Pritzlaff M, Horton C, Keith S. Germline Variant Spectrum Among African American Men Undergoing Prostate Cancer Germline Testing: Need for Equity in Genetic Testing. JCO Precision Oncology 2022, 6: e2200234. PMID: 35666082, PMCID: PMC9200399, DOI: 10.1200/po.22.00234.Peer-Reviewed Original ResearchConceptsGermline testingAA menWhite menHereditary cancer assessmentStandard clinical testingCohort of menAfrican American menGermline evaluationMultivariable analysisClinical managementBorderline associationLP variantsVariant statusClinical testingGermline analysisPanel testingRate of variantsCare deliveryVariant spectrumGenetic testingCancer assessmentUncertain significanceDNA repair genesGenetic counselingAmerican men
2016
Hereditary cancer syndromes and prostate cancer development among African American men: The importance of complete family cancer history.
Obeid E, Hegarty S, Bealin L, Montgomery S, Gross L, Chen D, Giri V. Hereditary cancer syndromes and prostate cancer development among African American men: The importance of complete family cancer history. Journal Of Clinical Oncology 2016, 34: e16625-e16625. DOI: 10.1200/jco.2016.34.15_suppl.e16625.Peer-Reviewed Original Research
2013
Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men
Hughes L, Ruth K, Rebbeck T, Giri V. Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men. Prostate Cancer And Prostatic Diseases 2013, 16: 308-314. PMID: 24061634, PMCID: PMC3865712, DOI: 10.1038/pcan.2013.36.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk Assessment ProgramAfrican American menHigh-risk menCC/CTProstate cancerCancer diagnosisIL-16Family historyProstate cancer screening strategiesProstate cancer risk assessmentCancer Risk Assessment ProgramIL-16 genotypesLongitudinal screening programCancer screening strategiesProstate cancer screeningTaqMan SNP genotyping assaysProstate cancer developmentPersonalized risk estimatesAfrican AmericansCancer risk assessmentGenetic variantsHazard ratioSNP genotyping assaysCancer screeningScreening program
2012
Assessing the Clinical Role of Genetic Markers of Early-Onset Prostate Cancer among High-Risk Men Enrolled in Prostate Cancer Early Detection
Hughes L, Zhu F, Ross E, Gross L, Uzzo R, Chen D, Viterbo R, Rebbeck T, Giri V. Assessing the Clinical Role of Genetic Markers of Early-Onset Prostate Cancer among High-Risk Men Enrolled in Prostate Cancer Early Detection. Cancer Epidemiology Biomarkers & Prevention 2012, 21: 53-60. PMID: 22144497, PMCID: PMC3253936, DOI: 10.1158/1055-9965.epi-11-0727.Peer-Reviewed Original ResearchConceptsEarly-onset prostate cancerProstate cancer early detectionHigh-risk menCancer early detectionAfrican American menProstate cancerEarly detectionAmerican menConcordance indexClinical informationProstate cancer risk assessmentCancer diagnosisHarrell's concordance indexAfrican American raceFamilial prostate cancerUseful clinical informationCancer risk assessmentStudy criteriaLongitudinal cohortFamily historyAge 35Clinical roleCox modelEligibility criteriaAmerican race
2011
Rates and predictors of colorectal cancer screening by race among motivated men participating in a prostate cancer risk assessment program
Hall M, Ruth K, Giri V. Rates and predictors of colorectal cancer screening by race among motivated men participating in a prostate cancer risk assessment program. Cancer 2011, 118: 478-484. PMID: 21751189, PMCID: PMC3195866, DOI: 10.1002/cncr.26315.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk Assessment ProgramCancer Risk Assessment ProgramAfrican American menUptake of CRCPredictors of uptakeCRC screeningLower endoscopyRisk assessment programAmerican menProstate cancerFamily historyFecal occult blood testingFecal occult blood testFox Chase Cancer CenterOccult blood testingColorectal cancer mortalityOccult blood testColorectal cancer screeningMultivariate logistic regressionProstate cancer clinicBlood testsBlood testingCancer CenterCancer mortalityCancer screening
2010
Racial differences in prediction of time to prostate cancer diagnosis in a prospective screening cohort of high‐risk men: effect of TMPRSS2 Met160Val
Giri V, Ruth K, Hughes L, Uzzo R, Chen D, Boorjian S, Viterbo R, Rebbeck T. Racial differences in prediction of time to prostate cancer diagnosis in a prospective screening cohort of high‐risk men: effect of TMPRSS2 Met160Val. BJU International 2010, 107: 466-470. PMID: 20735386, PMCID: PMC3052292, DOI: 10.1111/j.1464-410x.2010.09522.x.Peer-Reviewed Original ResearchConceptsHigh-risk menPCa diagnosisCaucasian manElevated prostate-specific antigen concentrationPCa screeningProstate Cancer Risk Assessment ProgramProstate-specific antigen concentrationCancer Risk Assessment ProgramProspective screening cohortCancer diagnosisProspective screening programCT/TTSecond-degree relativesAfrican American menTMPRSS2-ERG fusionUnderwent biopsyScreening cohortStudy entryAA menDegree relativesScreening programBRCA1/2 mutationsSelf-identified raceCox modelGene polymorphisms
2009
Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high‐risk screening population
Kaplan D, Boorjian S, Ruth K, Egleston B, Chen D, Viterbo R, Uzzo R, Buyyounouski M, Raysor S, Giri V. Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high‐risk screening population. BJU International 2009, 105: 334-337. PMID: 19709072, PMCID: PMC2809782, DOI: 10.1111/j.1464-410x.2009.08793.x.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk Assessment ProgramProstate Cancer Prevention Trial Risk CalculatorProstate cancer riskHigh-risk menProstate cancerPSA levelsRisk scoreFamily historyAfrican American menPCPT calculatorRisk calculatorCancer riskLower baseline prostate-specific antigen levelsBaseline prostate-specific antigen levelLow baseline PSA levelsProstate-specific antigen levelCancer Risk Assessment ProgramBaseline PSA levelsMedian PSA levelRisk of diagnosisBaseline risk scoreMedian risk scoreProstate cancer ratesProstate cancer diagnosisPrevious biopsyPrevalence and correlates of vitamin D status in African American men
Tseng M, Giri V, Bruner D, Giovannucci E. Prevalence and correlates of vitamin D status in African American men. BMC Public Health 2009, 9: 191. PMID: 19534831, PMCID: PMC2708155, DOI: 10.1186/1471-2458-9-191.Peer-Reviewed Original ResearchConceptsVitamin D insufficiencyVitamin D statusAfrican American menIU/dayVitamin D intakeD insufficiencyD statusD intakeAmerican menOdds ratioLow vitamin D statusSupplemental vitamin D intakeBlood collectionVitamin D recommendationsBody mass indexRecreational physical activitySignificant inverse associationHealth history questionnaireCross-sectional analysisD recommendationsMass indexBackgroundFew studiesInverse associationProstate cancerPhysical activityRace, Genetic West African Ancestry, and Prostate Cancer Prediction by Prostate-Specific Antigen in Prospectively Screened High-Risk Men
Giri V, Egleston B, Ruth K, Uzzo R, Chen D, Buyyounouski M, Raysor S, Hooker S, Torres J, Ramike T, Mastalski K, Kim T, Kittles R. Race, Genetic West African Ancestry, and Prostate Cancer Prediction by Prostate-Specific Antigen in Prospectively Screened High-Risk Men. Cancer Prevention Research 2009, 2: 244-250. PMID: 19240249, PMCID: PMC2652509, DOI: 10.1158/1940-6207.capr-08-0150.Peer-Reviewed Original ResearchConceptsBaseline prostate-specific antigenProstate-specific antigenSelf-reported raceAfrican American menProstate cancerAmerican menProstate Cancer Risk Assessment ProgramCancer Risk Assessment ProgramEarly detectionProstate cancer early detectionHigh-risk cohortWest African ancestryAfrican American raceHigh-risk menLow PSA valuesProportional hazards modelRace-specific differencesProstate cancer predictionCancer early detectionEuropean American menAfrican ancestryHazard ratioPSA valuesFamily historyBRCA1/2 mutations