2019
Prevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men
Chandrasekar T, Gross L, Gomella L, Hegarty S, Leong J, Giri V. Prevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men. European Urology Oncology 2019, 3: 291-297. PMID: 31278035, DOI: 10.1016/j.euo.2019.06.010.Peer-Reviewed Original ResearchConceptsHereditary cancer syndromesProstate cancerCancer syndromesFamily historyGermline mutationsExact testHereditary breastGenetic testingAfrican AmericansPCa family historyAfrican American patientsOvarian cancer syndromeCascade genetic testingFisher's exact testHereditary prostate cancerBRCA mutationsLynch syndromeOvarian cancerSyndromeCancerCascade testingDiverse cohortAA participantsSpectrum of genesFHx
2013
Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men
Hughes L, Ruth K, Rebbeck T, Giri V. Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men. Prostate Cancer And Prostatic Diseases 2013, 16: 308-314. PMID: 24061634, PMCID: PMC3865712, DOI: 10.1038/pcan.2013.36.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk Assessment ProgramAfrican American menHigh-risk menCC/CTProstate cancerCancer diagnosisIL-16Family historyProstate cancer screening strategiesProstate cancer risk assessmentCancer Risk Assessment ProgramIL-16 genotypesLongitudinal screening programCancer screening strategiesProstate cancer screeningTaqMan SNP genotyping assaysProstate cancer developmentPersonalized risk estimatesAfrican AmericansCancer risk assessmentGenetic variantsHazard ratioSNP genotyping assaysCancer screeningScreening programGlobal Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent
Rebbeck T, Devesa S, Chang B, Bunker C, Cheng I, Cooney K, Eeles R, Fernandez P, Giri V, Gueye S, Haiman C, Henderson B, Heyns C, Hu J, Ingles S, Isaacs W, Jalloh M, John E, Kibel A, Kidd L, Layne P, Leach R, Neslund-Dudas C, Okobia M, Ostrander E, Park J, Patrick A, Phelan C, Ragin C, Roberts R, Rybicki B, Stanford J, Strom S, Thompson I, Witte J, Xu J, Yeboah E, Hsing A, Zeigler-Johnson C. Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent. Prostate Cancer 2013, 2013: 560857. PMID: 23476788, PMCID: PMC3583061, DOI: 10.1155/2013/560857.Peer-Reviewed Original ResearchCAP incidenceSignificant public health problemProstate cancer incidenceAfrican descentPublic health problemLower mortality rateSub-Saharan AfricaHigher proportionAdvanced tumorsTumor stageCancer incidenceProstate cancerMortality rateProstate tumorsCancer ConsortiumHealth problemsMortalityIncidenceHealth careMenPercent gross domestic productAfrican AmericansTumorsCancerEstimated number