2022
Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing
Loeb S, Cheng H, Leader A, Gross L, Nolasco T, Byrne N, Wise D, Hollifield L, Brown L, Slater E, Pieczonka C, Gomella L, Kelly W, Trabulsi E, Handley N, Lallas C, Chandrasekar T, Mille P, Mann M, Mark J, Brown G, Chopra S, Wasserman J, Phillips J, Somers P, Giri V. Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing. Contemporary Clinical Trials 2022, 119: 106821. PMID: 35710085, DOI: 10.1016/j.cct.2022.106821.Peer-Reviewed Original ResearchConceptsKey patient-reported outcomesGermline testingPatient-reported outcomesProstate cancerGenetic counselingCollaborative care strategiesProstate cancer careTwo-armed randomizedProstate Cancer FoundationEducation/counselingGermline evaluationGOV IDENTIFIERPrimary outcomeSecondary outcomesStudy armsTarget enrollmentAshkenazi Jewish ancestryCancer careFamily historyTumor featuresCancer FoundationCare strategiesDecisional conflictUS sitesPractice settingsVirtual genetics board for enhancing knowledge and practice of prostate cancer genetic testing: The ENGAGEMENT study.
Giri V, Gross L, Cheng H, Russo J, Paller C, Johnson J, Weg E, Loeb S. Virtual genetics board for enhancing knowledge and practice of prostate cancer genetic testing: The ENGAGEMENT study. Journal Of Clinical Oncology 2022, 40: 184-184. DOI: 10.1200/jco.2022.40.6_suppl.184.Peer-Reviewed Original ResearchMetastatic prostate cancerProstate cancerGermline testingGenetic counselingRisk of PCaEarly-stage prostate cancerBaseline surveyHigh-risk diseaseStandard of careCancer genetic testingCancer genetics knowledgeMedical oncologistsMedical oncologyClinical trial managementClinical trialsNurse practitionersCancer managementAcademic centersFavorable responseCase discussionRadiation oncologistsPCa screeningKnowledge scoreGenetic testingPractice settings
2021
Helix: A Digital Tool to Address Provider Needs for Prostate Cancer Genetic Testing in Clinical Practice
Giri V, Walker A, Gross L, Trabulsi E, Lallas C, Kelly W, Gomella L, Fischer C, Loeb S. Helix: A Digital Tool to Address Provider Needs for Prostate Cancer Genetic Testing in Clinical Practice. Clinical Genitourinary Cancer 2021, 20: e104-e113. PMID: 35012874, DOI: 10.1016/j.clgc.2021.11.009.Peer-Reviewed Original ResearchConceptsGermline testingFamily historyClinical practiceChronic Diseases frameworkMultiple family historyMaternal family historyCancer genetic testingMedical oncologistsAdvanced PCaPCa riskProvider interviewsAggressive PCaRadiation oncologistsPractice settingsGenetic testingLarger studyDisease frameworkClinical useOncologistsLower ratesPractice gapMenDescriptive statisticsPhiladelphia areaProvidersPretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs
Russo J, McDougall C, Bowler N, Shimada A, Gross L, Hyatt C, Kelly W, Calvaresi A, Handley N, Hirsch I, Izes J, Lallas C, Mann M, Mark J, Mille P, Preate D, Trabulsi E, Tsang M, Chandrasekar T, Weiner P, Gomella L, Giri V. Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs. JCO Precision Oncology 2021, 5: 1377-1386. PMID: 34589662, PMCID: PMC8462590, DOI: 10.1200/po.21.00238.Peer-Reviewed Original ResearchConceptsGermline testingProstate cancerGenetic counselingDecisional conflictComparable patient-reported outcomesHereditary cancer assessmentPatient-reported outcomesCancer genetics knowledgePCa diagnosisPractice settingsPrecision careCancer assessmentInformed consentCategorical variablesSubstantial proportionGenetic knowledgeSignificant differencesContinuous variablesHigh rateMenPractice needsDescriptive statisticsProstate oncologyOutcomesCounselingBarriers and facilitators of germline genetic evaluation for prostate cancer
Loeb S, Li R, Nolasco T, Byrne N, Cheng H, Becker D, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. The Prostate 2021, 81: 754-764. PMID: 34057231, DOI: 10.1002/pros.24172.Peer-Reviewed Original ResearchConceptsCoordination of careProstate cancerChronic Diseases frameworkGuideline-concordant careGermline testingMedical oncologistsPatient factorsPhysicians' knowledgePhysician educationRadiation oncologistsPractice settingsDisease frameworkThematic saturationGenetic counselingGenetic evaluationCareOncologistsRecent dataCancerConstant comparative methodInterview guidePhysiciansNumerous barriersQualitative studyInterview transcriptsBarriers and facilitators of germline genetic evaluation for prostate cancer.
Loeb S, Li R, Sanchez Nolasco T, Byrne N, Cheng H, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. Journal Of Clinical Oncology 2021, 39: 28-28. DOI: 10.1200/jco.2021.39.6_suppl.28.Peer-Reviewed Original ResearchCoordination of careProstate cancerGenetic testingChronic Diseases frameworkGuideline-concordant careGermline genetic testingMetastatic prostate cancerGenetic counselingGermline testingLocalized diseasePatient factorsMedical oncologistsTherapeutic optionsCancer screeningPhysicians' knowledgeCurrent guidelinesPhysician educationRecent approvalRadiation oncologistsPractice settingsCancerDisease frameworkThematic saturationProstate Cancer GeneticsGenetic evaluation
2020
Clinical Implications of Germline Testing in Newly Diagnosed Prostate Cancer
Loeb S, Giri V. Clinical Implications of Germline Testing in Newly Diagnosed Prostate Cancer. European Urology Oncology 2020, 4: 1-9. PMID: 33390340, DOI: 10.1016/j.euo.2020.11.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGermline testingLocalized diseaseMetastatic PCaFamily historyGermline evaluationMetastatic diseaseCurrent guidelinesProstate cancerCancer riskPractice settingsGenetic testingDNA mismatch repair deficiencyManagement of menProstate cancer managementFamily cancer riskEarly-stage PCaMismatch repair deficiencyHereditary cancer riskPathologic featuresHistologic featuresMedical oncologyCancer screeningPCa managementPCa riskConsensus panelKnowledge and practice regarding prostate cancer germline testing among urologists: Gaps to address for optimal implementation✰,✰✰
Loeb S, Byrne N, Walter D, Makarov D, Wise D, Becker D, Giri V. Knowledge and practice regarding prostate cancer germline testing among urologists: Gaps to address for optimal implementation✰,✰✰. Cancer Treatment And Research Communications 2020, 25: 100212. PMID: 33091732, DOI: 10.1016/j.ctarc.2020.100212.Peer-Reviewed Original ResearchConceptsGermline testingProstate cancerUrologic practicePCa family historyLocalized prostate cancerMetastatic prostate cancerFamily history criteriaDiverse practice settingsHypothetical case scenariosGermline evaluationU.S. urologistsCancer screeningOvarian cancerPractice patternsFamily historySpecific histologicPCa prognosisNational guidelinesAmerican Urological Association sectionYounger agePractice settingsTesting guidelinesHistory criteriaUrologistsGenetic counseling