2022
Germline testing and genetic counselling in prostate cancer
Russo J, Giri V. Germline testing and genetic counselling in prostate cancer. Nature Reviews Urology 2022, 19: 331-343. PMID: 35449224, PMCID: PMC9022414, DOI: 10.1038/s41585-022-00580-7.Peer-Reviewed Original ResearchMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingGerm CellsHumansMaleProstatic NeoplasmsConceptsProstate cancerCancer risk managementCancer riskGenetic testingHereditary cancer predisposition syndromesPre-test discussionUnique clinical featuresGermline pathogenic variantsPrecision medicineHealth care professionalsComplex management optionsAdditional cancer riskCancer predisposition syndromeHereditary cancer riskGenetic counsellingGermline testingMetastatic diseaseClinical featuresOptimal careMedical historyFamily historyPathogenic variantsPrecision therapyGene testingCancerGenetic testing in prostate cancer management: Considerations informing primary care
Giri V, Morgan T, Morris D, Berchuck J, Hyatt C, Taplin M. Genetic testing in prostate cancer management: Considerations informing primary care. CA A Cancer Journal For Clinicians 2022, 72: 360-371. PMID: 35201622, DOI: 10.3322/caac.21720.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansMalePrimary Health CareProstatic NeoplasmsConceptsNational Comprehensive Cancer Network guidelinesProstate cancerPrimary careGenetic testingNetwork guidelinesFamily historyClinical trial optionsGermline genetic testingMetastatic prostate cancerPrimary care providersMultidisciplinary patient careProstate cancer managementRole of cliniciansHereditary cancer riskMultiple professional societiesComprehensive family historyPC survivorsGermline testingPC screeningAggressive diseasePoor outcomePC careClinical pathwayCancer managementCancer riskWhen to use germline genetic testing in prostate cancer.
Giri V. When to use germline genetic testing in prostate cancer. Clinical Advances In Hematology And Oncology 2022, 20: 78-81. PMID: 35120087.Commentaries, Editorials and LettersGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingGerm CellsGerm-Line MutationHumansMaleProstatic Neoplasms
2021
Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs
Russo J, McDougall C, Bowler N, Shimada A, Gross L, Hyatt C, Kelly W, Calvaresi A, Handley N, Hirsch I, Izes J, Lallas C, Mann M, Mark J, Mille P, Preate D, Trabulsi E, Tsang M, Chandrasekar T, Weiner P, Gomella L, Giri V. Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs. JCO Precision Oncology 2021, 5: 1377-1386. PMID: 34589662, PMCID: PMC8462590, DOI: 10.1200/po.21.00238.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionChoice BehaviorGenetic CounselingGenetic Predisposition to DiseaseHumansMaleMiddle AgedPatient Education as TopicProstatic NeoplasmsSurveys and QuestionnairesConceptsGermline testingProstate cancerGenetic counselingDecisional conflictComparable patient-reported outcomesHereditary cancer assessmentPatient-reported outcomesCancer genetics knowledgePCa diagnosisPractice settingsPrecision careCancer assessmentInformed consentCategorical variablesSubstantial proportionGenetic knowledgeSignificant differencesContinuous variablesHigh rateMenPractice needsDescriptive statisticsProstate oncologyOutcomesCounselingPhiladelphia Prostate Cancer Genetic Consensus Conference 2019 and implications for military medicine.
Peters C, Turner C, Chesnut G, Giri V, Gomella L, Shriver C, Dobi A. Philadelphia Prostate Cancer Genetic Consensus Conference 2019 and implications for military medicine. Canadian Journal Of Urology 2021, 28: 10659-10667. PMID: 34129457.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic Predisposition to DiseaseGenetic TestingHumansMaleMilitary MedicinePhiladelphiaProstatic Neoplasms
2020
Cancer Screening and Genetic Testing Recommendations for Relatives of Men Undergoing Prostate Cancer Germline Testing: Implications for Practice.
Giri V, Hyatt C, Leader A. Cancer Screening and Genetic Testing Recommendations for Relatives of Men Undergoing Prostate Cancer Germline Testing: Implications for Practice. Journal Of Urology 2020, 204: 1116-1118. PMID: 32926644, DOI: 10.1097/ju.0000000000001150.Peer-Reviewed Original Research
2018
Understanding of multigene test results among males undergoing germline testing for inherited prostate cancer: Implications for genetic counseling
Giri V, Obeid E, Hegarty S, Gross L, Bealin L, Hyatt C, Fang C, Leader A. Understanding of multigene test results among males undergoing germline testing for inherited prostate cancer: Implications for genetic counseling. The Prostate 2018, 78: 879-888. PMID: 29655297, PMCID: PMC6047906, DOI: 10.1002/pros.23535.Peer-Reviewed Original ResearchConceptsInherited prostate cancerProstate cancerGenetic counselingGenetic testingMultivariable linear regressionFamily history dataPre-test genetic counselingHigh baseline knowledgeSyndrome criteriaGermline testingMultivariable analysisMultigene testingMedical recordsFamily historyCancer riskSubset of malesMcNemar testUncertain significanceGEM participantsHigher knowledgeMeasures of knowledgeGenetic resultsMenGT resultsBaseline knowledge
2017
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017
Giri VN, Knudsen KE, Kelly WK, Abida W, Andriole GL, Bangma CH, Bekelman JE, Benson MC, Blanco A, Burnett A, Catalona WJ, Cooney KA, Cooperberg M, Crawford DE, Den RB, Dicker AP, Eggener S, Fleshner N, Freedman ML, Hamdy FC, Hoffman-Censits J, Hurwitz MD, Hyatt C, Isaacs WB, Kane CJ, Kantoff P, Karnes RJ, Karsh LI, Klein EA, Lin DW, Loughlin KR, Lu-Yao G, Malkowicz SB, Mann MJ, Mark JR, McCue PA, Miner MM, Morgan T, Moul JW, Myers RE, Nielsen SM, Obeid E, Pavlovich CP, Peiper SC, Penson DF, Petrylak D, Pettaway CA, Pilarski R, Pinto PA, Poage W, Raj GV, Rebbeck TR, Robson ME, Rosenberg MT, Sandler H, Sartor O, Schaeffer E, Schwartz GF, Shahin MS, Shore ND, Shuch B, Soule HR, Tomlins SA, Trabulsi EJ, Uzzo R, Vander Griend DJ, Walsh PC, Weil CJ, Wender R, Gomella LG. Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017. Journal Of Clinical Oncology 2017, 36: jco.2017.74.117. PMID: 29236593, PMCID: PMC6075860, DOI: 10.1200/jco.2017.74.1173.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProstate cancerGenetic testingMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerAggressive prostate cancerProstate cancer riskGenetic counselingMultidisciplinary consensus statementDNA mismatch repair genesExpert consensus conferenceFamilial prostate cancerHereditary prostate cancerClinical genetic testingMismatch repair genesMetastatic settingPCa managementLynch syndromeOvarian cancerBRCA2 mutationsConsensus statementFamily historyCancer riskHeterogeneous diseaseConsensus conferenceComprehensive genetic evaluationThe Role of Genetic Counseling in Familial and Sporadic Cancer: Considerations, Challenges, and Collaboration.
Giri V, Yurgelun M, Robson M. The Role of Genetic Counseling in Familial and Sporadic Cancer: Considerations, Challenges, and Collaboration. Annals Of Internal Medicine 2017, 167: 884-885. PMID: 29086794, DOI: 10.7326/m17-2512.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansInternal MedicineMedical History TakingNeoplasmsPhysician's RolePrecision Medicine
2016
How I Do It: Genetic counseling and genetic testing for inherited prostate cancer.
Giri V, Gross L, Gomella L, Hyatt C. How I Do It: Genetic counseling and genetic testing for inherited prostate cancer. Canadian Journal Of Urology 2016, 23: 8247-53. PMID: 27085833.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansMalePedigreePractice Guidelines as TopicProstatic NeoplasmsConceptsProstate cancer patientsProstate cancerCancer patientsGenetic counselingProstate cancer risk assessmentGenetic testing guidelinesInherited prostate cancerHereditary cancer syndromesCancer risk assessmentProstate cancer predispositionFamily historyUrologic communityCancer syndromesCancerGenetic testingPatientsTesting guidelinesGenetic mutationsCounselingCancer predispositionUrologistsCurrent knowledgeSubstantial heritable componentGenetic contributionProvidersHOXB13 and other high penetrant genes for prostate cancer
Pilie P, Giri V, Cooney K. HOXB13 and other high penetrant genes for prostate cancer. Asian Journal Of Andrology 2016, 18: 530-532. PMID: 27034017, PMCID: PMC4955175, DOI: 10.4103/1008-682x.175785.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic Predisposition to DiseaseGenotypeHomeodomain ProteinsHumansMaleProstatic NeoplasmsConceptsHereditary cancer syndromesMismatch repair genesCancer syndromesGermline mutationsProstate cancerMultiple primary malignanciesOvarian cancer syndromeCancer family syndromeDeleterious germline mutationsRare tumor typeCancer cell growthRepair genesHigh-penetrance genesPenetrant germline mutationsPrimary malignancyCommon cancerLi-FraumeniKey tumor suppressor genesFamily syndromeCancer tissuesHereditary breastTumor typesSyndromeCancer typesCancer
2015
Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer
Nicolas E, Arora S, Zhou Y, Serebriiskii I, Andrake M, Handorf E, Bodian D, Vockley J, Dunbrack R, Ross E, Egleston B, Hall M, Golemis E, Giri V, Daly M. Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget 2015, 6: 39614-39633. PMID: 26485759, PMCID: PMC4741850, DOI: 10.18632/oncotarget.5554.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Agents, PhytogenicCells, CulturedDNA Breaks, Double-StrandedDNA RepairEtoposideExomeFamily HealthGenetic Predisposition to DiseaseHistonesHumansINDEL MutationMaleMiddle AgedMutationPolymorphism, Single NucleotideProstatic NeoplasmsRisk AssessmentRisk FactorsSequence Analysis, DNAT-Lymphocytes
2014
Gene panel testing for inherited cancer risk.
Hall M, Forman A, Pilarski R, Wiesner G, Giri V. Gene panel testing for inherited cancer risk. Journal Of The National Comprehensive Cancer Network 2014, 12: 1339-46. PMID: 25190699, DOI: 10.6004/jnccn.2014.0128.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansNeoplastic Syndromes, HereditaryPenetranceRiskTargeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study
Bancroft E, Page E, Castro E, Lilja H, Vickers A, Sjoberg D, Assel M, Foster C, Mitchell G, Drew K, Mæhle L, Axcrona K, Evans D, Bulman B, Eccles D, McBride D, van Asperen C, Vasen H, Kiemeney L, Ringelberg J, Cybulski C, Wokolorczyk D, Selkirk C, Hulick P, Bojesen A, Skytte A, Lam J, Taylor L, Oldenburg R, Cremers R, Verhaegh G, van Zelst-Stams W, Oosterwijk J, Blanco I, Salinas M, Cook J, Rosario D, Buys S, Conner T, Ausems M, Ong K, Hoffman J, Domchek S, Powers J, Teixeira M, Maia S, Foulkes W, Taherian N, Ruijs M, Enden A, Izatt L, Davidson R, Adank M, Walker L, Schmutzler R, Tucker K, Kirk J, Hodgson S, Harris M, Douglas F, Lindeman G, Zgajnar J, Tischkowitz M, Clowes V, Susman R, Ramón y Cajal T, Patcher N, Gadea N, Spigelman A, van Os T, Liljegren A, Side L, Brewer C, Brady A, Donaldson A, Stefansdottir V, Friedman E, Chen-Shtoyerman R, Amor D, Copakova L, Barwell J, Giri V, Murthy V, Nicolai N, Teo S, Greenhalgh L, Strom S, Henderson A, McGrath J, Gallagher D, Aaronson N, Ardern-Jones A, Bangma C, Dearnaley D, Costello P, Eyfjord J, Rothwell J, Falconer A, Gronberg H, Hamdy F, Johannsson O, Khoo V, Kote-Jarai Z, Lubinski J, Axcrona U, Melia J, McKinley J, Mitra A, Moynihan C, Rennert G, Suri M, Wilson P, Killick E, Collaborators T, Moss S, Eeles R. Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study. European Urology 2014, 66: 489-499. PMID: 24484606, PMCID: PMC4105321, DOI: 10.1016/j.eururo.2014.01.003.Peer-Reviewed Original ResearchConceptsPositive predictive valueHigh-risk diseaseBRCA2 mutation carriersProstate cancerTargeted prostate cancerMutation carriersBRCA1/2 mutationsHigh riskProstate-specific antigen (PSA) testingProstate cancer screeningScreening resultsGermline BRCA1/2 mutationsFisher's exact testInitial screening roundGermline genetic markersIdentification of tumorsBreast cancer 1Germline genetic risk variantsBreast cancer 2PCa incidencePSA levelsAntigen testingTumor characteristicsAggressive diseaseBRCA2 carriers
2012
Assessing the Clinical Role of Genetic Markers of Early-Onset Prostate Cancer among High-Risk Men Enrolled in Prostate Cancer Early Detection
Hughes L, Zhu F, Ross E, Gross L, Uzzo R, Chen D, Viterbo R, Rebbeck T, Giri V. Assessing the Clinical Role of Genetic Markers of Early-Onset Prostate Cancer among High-Risk Men Enrolled in Prostate Cancer Early Detection. Cancer Epidemiology Biomarkers & Prevention 2012, 21: 53-60. PMID: 22144497, PMCID: PMC3253936, DOI: 10.1158/1055-9965.epi-11-0727.Peer-Reviewed Original ResearchConceptsEarly-onset prostate cancerProstate cancer early detectionHigh-risk menCancer early detectionAfrican American menProstate cancerEarly detectionAmerican menConcordance indexClinical informationProstate cancer risk assessmentCancer diagnosisHarrell's concordance indexAfrican American raceFamilial prostate cancerUseful clinical informationCancer risk assessmentStudy criteriaLongitudinal cohortFamily historyAge 35Clinical roleCox modelEligibility criteriaAmerican race
2011
A Systematic Review of Replication Studies of Prostate Cancer Susceptibility Genetic Variants in High-Risk Men Originally Identified from Genome-Wide Association Studies
Ishak M, Giri V. A Systematic Review of Replication Studies of Prostate Cancer Susceptibility Genetic Variants in High-Risk Men Originally Identified from Genome-Wide Association Studies. Cancer Epidemiology Biomarkers & Prevention 2011, 20: 1599-1610. PMID: 21715604, DOI: 10.1158/1055-9965.epi-11-0312.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideProstatic NeoplasmsValidation of Genome-Wide Prostate Cancer Associations in Men of African Descent
Chang B, Spangler E, Gallagher S, Haiman C, Henderson B, Isaacs W, Benford M, Kidd L, Cooney K, Strom S, Ingles S, Stern M, Corral R, Joshi A, Xu J, Giri V, Rybicki B, Neslund-Dudas C, Kibel A, Thompson I, Leach R, Ostrander E, Stanford J, Witte J, Casey G, Eeles R, Hsing A, Chanock S, Hu J, John E, Park J, Stefflova K, Zeigler-Johnson C, Rebbeck T. Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent. Cancer Epidemiology Biomarkers & Prevention 2011, 20: 23-32. PMID: 21071540, PMCID: PMC3110616, DOI: 10.1158/1055-9965.epi-10-0698.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesProstate cancer susceptibility regionsGenome-wide significanceGWAS-identified lociCancer susceptibility lociGenetic etiologyProstate cancer susceptibility allelesEuropean descentGenetic variationCancer susceptibility allelesEuropean-descent populationsAssociation studiesSusceptibility lociGenotype dataLociSusceptibility regionsChromosome 8q24Susceptibility allelesDescent populationsRegion 2Prostate cancer associationRs12418451MSMBRs10993994Alleles
2003
Genome‐wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1
Lange E, Gillanders E, Davis C, Brown W, Campbell J, Jones M, Gildea D, Riedesel E, Albertus J, Freas‐Lutz D, Markey C, Giri V, Dimmer J, Montie J, Trent J, Cooney K. Genome‐wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. The Prostate 2003, 57: 326-334. PMID: 14601029, DOI: 10.1002/pros.10307.Peer-Reviewed Original ResearchConceptsProstate cancer susceptibility genesCancer susceptibility genesSusceptibility genesCandidate genesGenome-wide scan dataGenome-wide analysisChromosome 17Michigan Prostate Cancer Genetics ProjectWhole-genome analysisCancer candidate genesProstate Cancer Genetics ProjectSubset of pedigreesStratified linkage analysesPrevious linkage studiesGenome analysisLinkage scanChromosome 1Genetic markersLinkage analysisAffected individualsGenesLinkage regionGenetics ProjectChromosome 17qProstate cancer families