1987
Developmental therapeutics and the acquired immunodeficiency syndrome.
DeVita V, Broder S, Fauci A, Kovacs J, Chabner B. Developmental therapeutics and the acquired immunodeficiency syndrome. Annals Of Internal Medicine 1987, 106: 568-81. PMID: 2435201, DOI: 10.7326/0003-4819-106-4-568.Peer-Reviewed Original ResearchConceptsHuman T-lymphotropic virus type IIIPotential screening targetsTreatment of AIDST4 subsetOverwhelming infectionImmunodeficiency syndromeOpportunistic infectionsDevelopmental therapeuticsImmune competenceAntiviral drugsViral DNA polymeraseScreening targetsType IIIInfectionAIDSViral integrationDrugsSpecific targetsEncouraging resultsPatientsSyndromeLymphocytes
1976
Pneumocystis Pneumonia
MICHAELIS L, LEIGHT G, POWELL R, DEVITA V. Pneumocystis Pneumonia. Annals Of Surgery 1976, 183: 301-306. PMID: 1083218, PMCID: PMC1344242, DOI: 10.1097/00000658-197603000-00016.Peer-Reviewed Original ResearchConceptsOpen lung biopsyMajor surgical proceduresSmall anterior thoracotomyCause of deathEarly thoracotomyAnterior thoracotomyLung biopsyMost patientsPulmonary infectionIll patientsSusceptible patientsInappropriate therapyGeneral anesthesiaInfected patientsPneumocystis pneumoniaHematologic malignanciesTherapeutic courseSurgical proceduresEffective treatmentPatientsPneumocystis cariniiInfectionThoracotomyTreatmentImmediate identification
1973
MAINTENANCE CHEMOTHERAPY FOR ADVANCED HODGKIN'S DISEASE IN REMISSION
Young R, Chabner B, Canellos G, Schein P, Devita V. MAINTENANCE CHEMOTHERAPY FOR ADVANCED HODGKIN'S DISEASE IN REMISSION. The Lancet 1973, 301: 1339-1343. PMID: 4122739, DOI: 10.1016/s0140-6736(73)91672-3.Peer-Reviewed Original ResearchConceptsMaintenance therapyIntermittent therapyAdvanced HodgkinMaintenance chemotherapyAdditional therapyComplete remissionInitial remissionMedian durationFurther therapyHodgkin's diseasePatientsTherapyRemissionEntire groupDiseaseChemotherapySignificant differencesSurvivalGroupPrednisoneRegimensComplicationsMustineVincristineInfection
1969
Pneumocystis carinii Pneumonia — Successful Diagnosis and Treatment of Two Patients with Associated Malignant Processes
DeVita V, Emmer M, Levine A, Jacobs B, Berard C. Pneumocystis carinii Pneumonia — Successful Diagnosis and Treatment of Two Patients with Associated Malignant Processes. New England Journal Of Medicine 1969, 280: 287-291. PMID: 5303991, DOI: 10.1056/nejm196902062800602.Peer-Reviewed Original ResearchConceptsNeedle biopsyMalignant processPentamidine isethionatePneumocystis carinii pneumoniaProper clinical settingPotential renal toxicityRenal functionAdequate therapyCarinii pneumoniaRenal toxicityPneumocystis infectionTubular disordersTherapeutic efficacyClinical settingFurther experiencePatientsBiopsyIsethionateTherapyInfectionDiagnosisValid assessmentPneumoniaPhysiciansDose