Dibromomannitol in the Treatment of Chronic Granulocytic Leukemia: A Prospective Randomized Comparison With Busulfan
Canellos G, Young R, Nieman P, DeVita V. Dibromomannitol in the Treatment of Chronic Granulocytic Leukemia: A Prospective Randomized Comparison With Busulfan. Blood 1975, 45: 197-203. DOI: 10.1182/blood.v45.2.197.197.Peer-Reviewed Original ResearchTreatment of chronic granulocytic leukemiaBusulfan-treated patientsChronic granulocytic leukemiaGranulocytic leukemiaRandomized comparisonMedian duration of disease controlChronic phase of CGLDuration of disease controlContinuous maintenance therapyElevated leukocyte countTreated with busulfanProspective randomized comparisonIncreased skin pigmentationMyelosuppressive actionRemission inductionMedian survivalMaintenance therapyMedian durationBlastic transformationPulmonary fibrosisBusulfanChronic phaseLeukocyte countDibromomannitolPatients