AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS
Camell C, Dixit V. AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS. Innovation In Aging 2019, 3: s106-s106. PMCID: PMC6845598, DOI: 10.1093/geroni/igz038.397.Peer-Reviewed Original ResearchFat-associated lymphoid clustersTissue B cellsB cell expansionAdipose tissueB cellsNLRP3 inflammasomeAdipose tissue immune cellsVisceral white adipose tissueB cell profileB-cell depletionB cell accumulationTissue immune cellsVisceral adipose tissueWhite adipose tissueAged B cellsFALC formationVisceral adiposityCell depletionInduces NLRP3Aged miceImmune cellsInsulin sensitivityFemale miceLymphoid clustersMetabolic dysfunctionNLRP3 Inflammasome regulation of lipolysis in aged adipose tissue
Camell C, Dixit V. NLRP3 Inflammasome regulation of lipolysis in aged adipose tissue. The FASEB Journal 2019, 33: 78.2-78.2. DOI: 10.1096/fasebj.2019.33.1_supplement.78.2.Peer-Reviewed Original ResearchAdipose tissue macrophagesAge-related reductionAdipose triglyceride lipaseHormone-sensitive lipaseVisceral adiposityFree fatty acidsAdipose tissueNLRP3 inflammasome-dependent mannerDeletion of NLRP3Inflammasome-dependent mannerTissue NE concentrationLower exercise capacityAge-related inflammationSympathetic nervous systemDiet-induced obesityImmune-metabolic interactionsCatecholamine-induced lipolysisWhite adipose tissueFull-text articlesCore body temperatureExercise capacityKey lipolytic enzymeMetabolic dysfunctionFunctional declineLeukocyte alterations