2000
Secreted cathepsin L generates endostatin from collagen XVIII
Felbor U, Dreier L, Bryant R, Ploegh H, Olsen B, Mothes W. Secreted cathepsin L generates endostatin from collagen XVIII. The EMBO Journal 2000, 19: 1187-1194. PMID: 10716919, PMCID: PMC305660, DOI: 10.1093/emboj/19.6.1187.Peer-Reviewed Original ResearchAnimalsCathepsin LCathepsinsCell LineCollagenCollagen Type XVIIICulture Media, ConditionedCysteine EndopeptidasesEndopeptidasesEndostatinsEndothelium, VascularEnzyme PrecursorsHumansHydrogen-Ion ConcentrationKineticsMatrix MetalloproteinasesMiceModels, BiologicalMolecular WeightPeptide FragmentsProtein Processing, Post-TranslationalProtein Structure, TertiaryRecombinant Fusion ProteinsTumor Cells, Cultured
1996
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
Wiertz E, Tortorella D, Bogyo M, Yu J, Mothes W, Jones T, Rapoport T, Ploegh H. Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 1996, 384: 432-438. PMID: 8945469, DOI: 10.1038/384432a0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateBiological Transport, ActiveCell LineCysteine EndopeptidasesCytomegalovirusCytosolEndoplasmic ReticulumGlycosylationHistocompatibility Antigens Class IHumansMembrane ProteinsMultienzyme ComplexesProteasome Endopeptidase ComplexProtein FoldingSEC Translocation ChannelsViral Proteins