Predictive Biomarkers in the Management of Bladder Cancer: Perspectives in an Evolving Therapeutic Landscape
Hensley P, Lobo N, Bree K, Tan W, Gontero P, Williams S, Guo C, Giannarini G, Dyrskjøt L, Kamat A. Predictive Biomarkers in the Management of Bladder Cancer: Perspectives in an Evolving Therapeutic Landscape. Société Internationale D’Urologie Journal 2022, 3: 245-257. DOI: 10.48083/rvzv1144.Peer-Reviewed Original ResearchPredictive biomarkersBladder cancerPredictive biomarkers of therapeutic responseBiomarkers of therapeutic responseManagement of bladder cancerBladder preservation strategiesSequence of therapyMuscle-invasive BCNon-muscle-invasiveEvolving therapeutic landscapeTherapeutic mechanism of actionAdvanced disease stateLikelihood of responseSerum-based biomarkersSystemic therapyTumor gradeTargeted therapyMechanism of actionTherapeutic responseHeterogeneous diseaseUrine-basedPrognostic capacityTherapeutic strategiesTherapeutic landscapeTherapyIntermediate-risk Non–muscle-invasive Bladder Cancer: Updated Consensus Definition and Management Recommendations from the International Bladder Cancer Group
Tan W, Steinberg G, Witjes J, Li R, Shariat S, Roupret M, Babjuk M, Bivalacqua T, Psutka S, Williams S, Cookson M, Palou J, Kamat A. Intermediate-risk Non–muscle-invasive Bladder Cancer: Updated Consensus Definition and Management Recommendations from the International Bladder Cancer Group. European Urology Oncology 2022, 5: 505-516. PMID: 35718695, DOI: 10.1016/j.euo.2022.05.005.Peer-Reviewed Original ResearchConceptsNon-muscle-invasive bladder cancerInternational Bladder Cancer GroupBladder cancer groupManagement of patientsIntermediate-riskIntravesical treatmentCancer groupRisk factorsClinical trialsIntravesical chemotherapyMultifocal tumorsEarly recurrenceTumor sizeBladder cancerFrequent recurrenceHeterogeneous diseaseGrading systemCarcinoma in situStage of tumorPostoperative intravesical chemotherapyRandomized clinical trialsMaintenance BCGComparison of outcomesRecurrent diseaseClinical practice guidance