Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells
SUN L, LI G, DAI B, TAN W, ZHAO H, LI X, WANG A. Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. Molecular Medicine Reports 2015, 12: 3423-3431. PMID: 26043756, PMCID: PMC4526050, DOI: 10.3892/mmr.2015.3886.Peer-Reviewed Original ResearchConceptsShort hairpin RNAFluorescence-activated cell sortingInhibition of cell proliferationRNA interferenceCell invasionCell apoptosisCell proliferationPhase cell cycle arrestG0/G1 phase cell cycle arrestCell cycle arrestEnhancement of apoptosisExpression levelsInhibition of cell invasionGlioma cellsHuman malignant glioma cellsHuman glioma progressionExpression levels of MACC1MACC1 silencingColony formGlioma progressionCycle arrestCaspase-3Genetic therapeutic strategiesExpression silencingGlioma cell proliferation