2018
Does urinary cytology have a role in haematuria investigations?
Tan W, Sarpong R, Khetrapal P, Rodney S, Mostafid H, Cresswell J, Watson D, Rane A, Hicks J, Hellawell G, Davies M, Srirangam S, Dawson L, Payne D, Williams N, Brew‐Graves C, Feber A, Kelly J, Sridhar A, Lamb B, Ocampo F, McBain H, Baillie K, Middleton K, Knight H, Maher S, Pathmanathan B, Harmathova A, Pelluri S, Pati J, Cossons A, Scott C, Madaan S, Bradfield S, Wakeford N, Dann, Cook J, Cornwell M, Mills R, Thomas, Reyner S, Vallejera G, Adeniran P, Masood S, Whotton N, Dent K, Pearson S, Hatton J, Newton M, Hheeney E, Green K, Evans S, Rogers M, Gupwell K, ley S, Brown A, McGrath J, Lunt N, Hill P, inclair A, Paredes‐Guerra A, Holbrook B, Ong E, Wardle H, Wilson D, Bayles A, Fennelly R, Tribbeck M, Ames K, Taylor J, Edmunds E, Moore J, Mckinley S, Nolan T, peed A, Tunnicliff A, Fossey G, Williams A, George M, Hutchins I, Einosas R, Richards A, Henderson A, Appleby B, Kehoe L, Gladwell L, Drakeley S, Davies J, Krishnan R, Roberts H, Main C, Jain S, Dumville J, Wilkinson N, Taylor J, Thomas F, Goulden K, Vinod C, Green E, Waymont C, Rogers J, Grant A, Carter V, Heap H, Lomas C, Cooke P, Scarratt L, Hodgkiss T, Johnstone D, Johnson J, Allsop J, Rothwell J, Connolly K, Cherian J, Ridgway S, Coulding M, Savill H, Mccormick J, Clark M, Collins G, Jewers K, Keith S, Bowen G, Hargreaves J, Riley K, Rees A, Williams S, Dukes S, Goffe A, Mistry R, Chadwick J, Cocks S, Hull R, oftus A, Baird Y, Moore S, Greenslade S, Margalef J, Chadbourn I, Harris M, Clitheroe P, Connolly S, Hodgkinson S, Haydock H, Storr E, Cogley L, Natale S, Lovegrove W, Slack K, Nash D, Smith K, Walsh J, Guerdette A, Hill M, Taylor B, Sinclair E, Perry M, Debbarma M, Hewitt D, Sriram R, Power A, Cannon J, Devereaux L, Thompson A, Atkinson K, Royle L, Madine J, MacLean K. Does urinary cytology have a role in haematuria investigations? BJU International 2018, 123: 74-81. PMID: 30003675, PMCID: PMC6334509, DOI: 10.1111/bju.14459.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Transitional CellFalse Negative ReactionsFalse Positive ReactionsFemaleHematuriaHumansKidney NeoplasmsMaleMiddle AgedNeoplasm GradingNeoplasm StagingPredictive Value of TestsProspective StudiesTomography, X-Ray ComputedUltrasonographyUreteral NeoplasmsUrinary Bladder NeoplasmsUrineUrographyConceptsUpper tract urothelial cancerPositive urine cytologyAccuracy of urinary cytologyDiagnosis of bladder cancerUrine cytologyHigh-risk cancerNegative predictive valuePositive predictive valueBladder cancerHaematuria investigationsUrinary cytologyInvasive testingDiagnostic accuracy of urinary cytologyMuscle-invasive bladder cancerProspective observational study of patientsMulticentre prospective observational studyObservational study of patientsPredictive valueEndoscopic tumor resectionPositive cytology resultsUpper tract imagingHigh-risk diseaseOutcomes of patientsDiagnosed bladder cancerStudy of patientsNovel urinary biomarkers for the detection of bladder cancer: A systematic review
Tan W, Tan W, Tan M, Khetrapal P, Dong L, deWinter P, Feber A, Kelly J. Novel urinary biomarkers for the detection of bladder cancer: A systematic review. Cancer Treatment Reviews 2018, 69: 39-52. PMID: 29902678, DOI: 10.1016/j.ctrv.2018.05.012.Peer-Reviewed Original ResearchConceptsNegative predictive valuePositive predictive valueUrinary biomarkersBladder cancerReceiver operating characteristicRisk of biasPredictive valueNon-muscle invasive bladder cancer patientsBiomarkers investigated to dateInvasive bladder cancer patientsDetection of bladder cancerDiagnosis of bladder cancerSystematic reviewNovel urinary biomarkersBladder cancer patientsQUADAS-2 toolCase-control studyAssessed risk of biasSpecificity of biomarkersPositive test resultsSystematic searchUrinary cytologySurveillance cystoscopyComprehensive systematic reviewQUADAS-2Can Renal and Bladder Ultrasound Replace Computerized Tomography Urogram in Patients Investigated for Microscopic Hematuria?
Tan W, Sarpong R, Khetrapal P, Rodney S, Mostafid H, Cresswell J, Hicks J, Rane A, Henderson A, Watson D, Cherian J, Williams N, Brew-Graves C, Feber A, Kelly J, Collaborators D. Can Renal and Bladder Ultrasound Replace Computerized Tomography Urogram in Patients Investigated for Microscopic Hematuria? Journal Of Urology 2018, 200: 973-980. PMID: 29702097, PMCID: PMC6179963, DOI: 10.1016/j.juro.2018.04.065.Peer-Reviewed Original ResearchConceptsUpper tract urothelial cancerComputerized tomography urogramBladder ultrasoundIncidence of bladderUrinary tract cancerMicroscopic hematuriaUrothelial cancerBladder cancerIncidence of upper tract urothelial cancerIncidence of urinary tract cancerRenal calculiPredictive valueUpper tract imagingDetecting bladder cancerNegative predictive valueDetect renal cancerDiagnosed bladder cancerPositive predictive valueSuspected renal calculiHematuria casesMacroscopic hematuriaRenal cancerHematuriaInvestigated patientsCystoscopy
2017
DETECT I & DETECT II: a study protocol for a prospective multicentre observational study to validate the UroMark assay for the detection of bladder cancer from urinary cells
Tan W, Feber A, Dong L, Sarpong R, Rezaee S, Rodney S, Khetrapal P, de Winter P, Ocampo F, Jalil R, Williams N, Brew-Graves C, Kelly J. DETECT I & DETECT II: a study protocol for a prospective multicentre observational study to validate the UroMark assay for the detection of bladder cancer from urinary cells. BMC Cancer 2017, 17: 767. PMID: 29141603, PMCID: PMC5688623, DOI: 10.1186/s12885-017-3758-7.Peer-Reviewed Original ResearchConceptsNon-muscle invasive bladder cancerNon-muscle invasive bladder cancer patientsBladder cancerSurveillance cystoscopyUrinary testsRisk of urinary tract infectionPresence of bladder cancerHigh grade bladder cancerDetection of bladder cancerProspective multicentre observational studyRecurrent bladder cancerUpper tract imagingInvasive bladder cancerUrinary sediment cellsUrinary tract infectionNegative predictive valueMulticentre observational studyGrade bladder cancerBladder cancer surveillanceCystoscopy findingsTract infectionsUrine sample collectionHistopathological resultsCystoscopyInvasive procedures
2015
Is Prebiopsy MRI Good Enough to Avoid Prostate Biopsy? A Cohort Study Over a 1-Year Period
Lamb B, Tan W, Rehman A, Nessa A, Cohen D, O'Neil J, Green J, Hines J. Is Prebiopsy MRI Good Enough to Avoid Prostate Biopsy? A Cohort Study Over a 1-Year Period. Clinical Genitourinary Cancer 2015, 13: 512-517. PMID: 26231912, DOI: 10.1016/j.clgc.2015.06.007.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingPrebiopsy multiparametric magnetic resonance imagingNational Comprehensive Cancer NetworkProstate multiparametric magnetic resonance imagingTransrectal ultrasound prostate biopsySignificant prostate cancerTransrectal ultrasound biopsyProstate biopsyTransrectal ultrasoundProstate cancerNational Comprehensive Cancer Network high-riskSensitivity of multiparametric magnetic resonance imagingDetect clinically significant prostate cancerSystematic 12-core prostate biopsyClinically significant prostate cancerMRI scansPredictive valueNegative MRI scansGleason score 8High-risk diseasePositive MRI scansNegative predictive valuePositive predictive valueComprehensive Cancer NetworkRisk of complications