CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
Feber A, Worth D, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R, Malone P, Tan W, Rodney S, Freeman A, Jameson C, Wilson G, Powles T, Beck S, Fenton T, Sharp T, Muneer A, Kelly J. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Cancer Research 2016, 76: 4720-4727. PMID: 27325650, PMCID: PMC5302160, DOI: 10.1158/0008-5472.can-15-3134.Peer-Reviewed Original ResearchMeSH KeywordsCadherinsCarcinoma, Squamous CellCOP9 Signalosome ComplexDNA Copy Number VariationsDNA MethylationDNA Mutational AnalysisFluorescent Antibody TechniqueHumansIntracellular Signaling Peptides and ProteinsMaleMutationPenile NeoplasmsPolymerase Chain ReactionConceptsWhole-exome sequencingResequencing of candidate genesPenile cancerMiRNA-mediated gene silencingCytoplasmic P-bodiesCopy-number informationAnalysis of somatic alterationsSomatic mutation landscapeDevelopment of penile cancerPenile squamous cell carcinomaTargeted resequencingCandidate genesDNA methylationGene silencingHPV-negative diseaseP-bodiesRecurrent mutationsLandscape of alterationsAPOBEC mutational signaturesSquamous cell carcinomaGermline DNASomatic alterationsMutation dataMutational signaturesGenetic alterations