2024
Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Medjimorec M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Nature Communications 2024, 15: 2839. PMID: 38565563, PMCID: PMC10987549, DOI: 10.1038/s41467-024-46540-0.Peer-Reviewed Original ResearchConceptsHead and neck dermatitisAtopic dermatitisNeck dermatitisT cellsHealthy control skinType 2 inflammationDupilumab treatmentImmune signaturesReceptor upregulationActivation markersClinical efficacyPunch biopsyHistopathological featuresDe novo appearanceIL-22Single-cell RNA sequencingDrug effectsDupilumabSide effectsControl skinDermatitisKeratinocyte activationUntreated ADTreatmentRNA sequencing
2023
Association between atopic dermatitis and inflammatory bowel disease among US adults in the All of Us Research Program
Joel M, Damsky W, Cohen J, Wride M. Association between atopic dermatitis and inflammatory bowel disease among US adults in the All of Us Research Program. Clinical And Experimental Dermatology 2023, 49: 390-392. PMID: 37967342, PMCID: PMC10957220, DOI: 10.1093/ced/llad397.Peer-Reviewed Original ResearchMachine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis
Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.Peer-Reviewed Original Research44140 Obsessive-Compulsive Disorder Among Patients with Atopic Dermatitis: A Case-Control Study in the All of Us Research Program
Chen G, Fan R, Leasure A, Damsky W, Cohen J. 44140 Obsessive-Compulsive Disorder Among Patients with Atopic Dermatitis: A Case-Control Study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 89: ab69. DOI: 10.1016/j.jaad.2023.07.279.Peer-Reviewed Original ResearchAssessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology
Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAtopic dermatitisSkin diseasesInflammatory skin diseaseInflammatory skin conditionImmunologic biomarkersImmune biomarkersPersonalized medicineInflammatory dermatosesImmunologic approachesTherapy selectionSkin conditionsSingle-cell RNA sequencingMolecular profilingBiomarkersTissue stainingPsoriasisDermatitisDiseaseDermatologyRNA sequencingMedicineCurettageDermatosesTherapyPersonalized classificationAssociation of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program
Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program. 2023 DOI: 10.21203/rs.3.rs-2782847/v1.Peer-Reviewed Original ResearchAtopic dermatitisSchizoaffective disorderRace/ethnicityUs Research ProgramMental health comorbiditiesElectronic health record dataCase-control studyMajor depressive disorderHealth record dataDiagnosis of schizophreniaHealth comorbiditiesMultivariable analysisPathophysiologic mechanismsSmoking statusDepressive disorderAD casesSchizophreniaAnxiety disordersComparing RatesDisordersRecord dataNational InstituteFurther studiesPatientsDermatitisBaseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis
Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.Peer-Reviewed Original ResearchConceptsEczematous dermatitisHistologic featuresTreatment selectionType 1Type 3 inflammationInflammatory skin diseaseCertain histologic featuresSitu hybridization correlatesClinical responseNonresponder groupCytokine profileCytokine stainingAtopic dermatitisCytokine RNAEczematous disordersSitu hybridizationDupilumabIL13 expressionSkin diseasesType 2PatientsDermatitisNonrespondersMolecular heterogeneityImproved response
2022
The association of atopic dermatitis and chronic rhinosinusitis in adults: a cross‐sectional study using the All of Us research program
Hodelin C, Fan R, Damsky W, Cohen J. The association of atopic dermatitis and chronic rhinosinusitis in adults: a cross‐sectional study using the All of Us research program. International Journal Of Dermatology 2022, 62: e430-e431. PMID: 36468789, DOI: 10.1111/ijd.16544.Peer-Reviewed Original ResearchMigraine among adults with atopic dermatitis: a cross-sectional study in the All of Us research programme
Fan R, Leasure A, Damsky W, Cohen J. Migraine among adults with atopic dermatitis: a cross-sectional study in the All of Us research programme. Clinical And Experimental Dermatology 2022, 48: 24-26. PMID: 36669173, DOI: 10.1093/ced/llac004.Peer-Reviewed Original Research187 Mental health comorbidities and alcohol use disorder in atopic dermatitis: A case-control study in the All of Us research program
Fan R, Leasure A, Damsky W, Cohen J. 187 Mental health comorbidities and alcohol use disorder in atopic dermatitis: A case-control study in the All of Us research program. Journal Of Investigative Dermatology 2022, 142: s32. DOI: 10.1016/j.jid.2022.05.194.Peer-Reviewed Original Research