Pediatric cutaneous Crohn disease: A case series of 89 patients and review
McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, DOI: 10.1111/pde.15689.Peer-Reviewed Original ResearchBiologic therapyPediatric patientsCrohn's diseaseMetastatic Crohn's diseaseInterleukin-12/23 inhibitorsCutaneous granulomatous inflammationIntestinal Crohn's diseaseDiscordant therapyTNF blockadeOral corticosteroidsInterleukin-12/23Dual therapyRetrospective reviewPediatric casesCutaneous CDMechanism of actionPatient demographicsCase seriesChart reviewClinical characteristicsPartial clearanceGranulomatous inflammationCase of CCDSmall molecule inhibitorsCutaneous diseaseGranuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics
Mohanty C, Singh C, Daccache J, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields B. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Journal Of Investigative Dermatology 2024 PMID: 38844128, DOI: 10.1016/j.jid.2024.04.024.Peer-Reviewed Original ResearchGranuloma annulareGranulomatous inflammationFDA-approved therapiesInflammatory signaling cascadesImpact of GAIFN-gImmune cellsInterleukin-32Idiopathic conditionTh2 signalsAdaptive immunityInterstitial patternMacrophage activationGene expression changesMolecular driversQuality of lifeGenome-wide gene expression changesMacrophage polarizationGranulomaMacrophagesTissue remodelingInflammationTNF signalingLocal gene expression patternsSpatial transcriptomics