Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations
Giraldez S, Tamayo P, Wineinger N, Kim W, Reed S. Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations. IScience 2019, 19: 850-859. PMID: 31513970, PMCID: PMC6739637, DOI: 10.1016/j.isci.2019.08.043.Peer-Reviewed Original ResearchChromosomal copy number alterationsCopy number alterationsCyclin ECell cycle regulatory proteinsOverexpression of cyclin EChromosomal lociCyclin E overexpressionEpithelial cell clonesRegulatory proteinsReplication stressCell cycleAberrant mitosesS phaseEpithelial-like tumorsCyclinE overexpressionCell clonesClonesOncogenesisComputational approachReplicationPotential mechanismsChromosomal damageCellsLoci