Gαs (GNAS) suppression of the p53 genomic‐stability checkpoint unleashes RAS‐driven oncogenesis
Steffen D, Tiriac H, Valera J, Amornphimoltham P, Kim W, Taylor S, Hunter T, Tamayo P, Gutkind J. Gαs (GNAS) suppression of the p53 genomic‐stability checkpoint unleashes RAS‐driven oncogenesis. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.04604.Peer-Reviewed Original ResearchTrp53 tumor suppressor geneCooperation of rasMDM2-mediated p53 ubiquitinationHuman intestinal organoid modelP53 E3 ubiquitin ligaseSquamous cell carcinomaIn vitro ubiquitination assayP53 protein accumulationChemical carcinogen DMBASkin of adult miceTumor suppressor genePhosphorylation of Mdm2Control genome stabilityE3 ubiquitin ligaseRAS mutant tumorsRas-driven oncogenesisCarcinogenesis in vivoSubstrate of PKAConstitutively activating mutationAppendix cancerPan-cancer analysisActivation of signalingPatient sequencing dataBenign tumorsCell carcinoma