Abstract 5020: A genome-scale ORF screen reveals an alternative splicing program that regulates mesenchymal and stem-like cell states in breast cancer
Li J, Choi P, Chaffer C, Labella K, Kim J, Doench J, Dai C, Giacomelli A, Ly S, Hwang J, Hong A, Ilic N, Gjoerup O, Meyerson M, Brooks A, Weinberg R, Hahn W. Abstract 5020: A genome-scale ORF screen reveals an alternative splicing program that regulates mesenchymal and stem-like cell states in breast cancer. Cancer Research 2017, 77: 5020-5020. DOI: 10.1158/1538-7445.am2017-5020.Peer-Reviewed Original ResearchAlternative splicing programFilamin BSplicing factorsGene set enrichment analysisAlternative splicingCell statesSplicing programCD44 cell surface markersRegulation of EMTShort isoformStem-like stateDownstream targetsStem cell fate determinationCell fate determinationRNA splicing factorsHuman mammary epithelial cellsBreast cancer patient samplesMammary epithelial cellsBreast cancer cell linesRNA sequencing analysisTumor formation in vivoAssociated with stem cell propertiesBasal-like breast cancerCancer patient samplesStem-like traits